Our research program aims broadly at developing new mass spectrometry (MS) methods for bio-analysis. Research efforts are currently focused on utilizing radical reactions as a unique approach to providing the high level of structural information of proteins and lipids, such as disulfide linkage pattern and carbon-carbon double bond location. We are also developing new MS instrumentation to investigate the radical attack on biomolecules in the gas phase and characterizing a series of peptide or protein radicals which are of biological importance.
1. Gas-phase radical ion chemistry
Radical ions, which consist of unpaired electrons, offer distinct gas-phase ion chemistry as compared to the even-electron species. Radical chemistry can be utilized to tackle challenging problems, such as differentiating isomeric structures, which would otherwise not be solved by traditional MS analysis of even-electron ions of the biomolecules. We are developing MS instrumentation and methods to facilitate radical reactions for either in the vacuum or in ambient air.
1. Radical reactions...