Flexible Pt3Ni-S-Deposited Teflon Membrane with High Surface Mechanical Properties for Efficient Solar-Driven Strong Acidic/Alkaline Water Evaporation
Solar-driven water evaporation provides a promising solution to the energy crisis and environmental issues. Capitalizing on the high photothermal conversion efficiency and excellent resistance to strong acids or strong alkalis of Pt3Ni–S nanowires, we strategically design and prepare a flexible Pt3Ni–S-deposited Teflon (PTFE) membrane for achieving efficient strong acid/alkaline water evaporation under simulated sunlight irradiation (1 sun). By comparing the surface morphology, mechanical properties, and water evaporation performance of the as-prepared three different membranes, we have screened out a high-performance photothermal membrane that has good hydrophobicity (water contact angle = 106°), strong mechanical properties, high light-to-heat conversion efficiency (η = 80%), and excellent durability (10 cycles in a range of pH = 1.2–12). In particular, we explore the mechanism of high surface mechanical properties of the as-prepared membrane using density functional theory. The results demonstrate that the related mechanism can be ascribed to two main reasons: (1) hydrogen bonds can be formed between the 2-pyrrolidone ring and PTFE-3 and (2) the O atom in PTFE-3 carries more negative charge (−0.19 |e|) than PTFE-1 (−0.16 |e|) and PTFE-2 (−0.15 |e|). Our work highlights the great potentials of a Pt3Ni–S-deposited PTFE membrane as a device for implementing solar energy-driven evaporation of industrial wastewater with strong acidity or alkalinity and provides a new strategy for improving the surface mechanical properties of a photothermal membrane.
期刊:
ACS Appl. Mater. Interfaces
2020
作者:
Qu Fengyu*,Jingxiang Zhao,Yitong Cui,Yuzhu Wang,Ye Zhang,Le Zhao,Haixia Liu,Feng Zhang,Huiming Lin,Wei Guo,Chunyu Yang,Tianyue Ma
DOI:10.1021/acsami.0c04682
Construct of MoSe2/Bi2Se3 nanoheterostructure: Multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer treating
The development of nanotheranostic agent with imaging-guided highly therapeutic efficiency has attracted most attentions on tumor treatment. Herein, the novel MoSe2/Bi2Se3 nanosheets were designed to integrate CT/ photothermal (PT) imaging and photodynamic/photothermal/chemo-therapy (PTT/PDT/chemotherapy) into one nanoplatform. Firstly, the MoSe2 nanosheets (5–30 nm) were prepared via ultrasound-assisted exfoliated method, and then by a cation-exchange strategy the novel sandwich nanostructure Bi2Se3/MoSe2/Bi2Se3 (Bi-M-3) were obtained, revealing the narrower band gap (1.17 eV) and the stronger near-infrared (NIR) absorption.
Both experimental and density functional theory (DFT) calculations reveal the Z-scheme mechanism of charge transfer in the heterostructure, which induces the enhanced ROS (⋅OH) generation due to the efficient separation of photogenerated electron-hole pairs. Meanwhile, the nanoheterostructure also makes sure the improved photothermal conversion efficiency (59.3%). Besides, we also found the photothermal effect can promote the transfer photo-generated electron that is in favor of ROS generation. Furthermore, because of the higher absorption
coefficient of X-ray for Bi atom, the heterostructure also exhibits the higher CT imaging contrast than pure MoSe2 sample. After the loading of anticancer drug Doxorubicin (Dox), Bi-M-3@PEG-Dox displays the acid/photothermal sensitive drug release behavior. The synergistic effect of chemotherapy, photodynamic and photothermal therapy further induces the superior cancer cell apoptosis and enhanced antitumor effect.
期刊:
Biomaterials
2019
作者:
Fengyu Qu*,Huiming Lin,...,Kai Wang,Wei Guo,Qian Wang,Feng Zhang,Zhe Chen,Jingxiang Zhao,Ying Wang
DOI:10.1016/j.biomaterials.2019.119282
SnxWO3 as a theranostic platform for realizing multi-imaging-guided photothermal/photodynamic
combination therapy
Precise oncotherapy requires effective cancer treatments that are guided by clinical imaging techniques.
One of the most representative cases is multi-imaging-guided phototherapy. This study presents a novel
multifunctional theranostic agent of SnxWO3 tungsten bronze, which is an excellent light absorber in the
near infrared (NIR) range. Theoretical calculations based on density functional theory confirm that the
insertion of donor Sn atoms into orthorhombic WO3 gives rise to the broadband visible-NIR absorption.
Accordingly, both the photothermal effect and reactive oxygen species (ROS) production could be realized
under NIR light irradiation by SnxWO3 tungsten bronze nanocrystals, thereby triggering the potent
in vivo photothermal and photodynamic synergistic therapy. Meanwhile, modified SnxWO3 tungsten
bronze has the functions of photoacoustic imaging (PAI), X-ray computed tomography (CT) imaging and
near-infrared fluorescence (NIRF) imaging for tumor detection as well. Finally, for investigating the antitumor
mechanism of in vivo solid tumors, clinical imaging modalities of B-mode ultrasonography (US)
and magnetic resonance imaging (MRI) are employed to monitor the tumor evolution process after the
photo-treatment, verifying a typically liquefactive necrosis process. These results indicate that the SnxWO3
tungsten bronze nanostructure is a promising theranostic agent for imaging-guided cancer therapy.
期刊:
Nanoscale
2019
作者:
Yanling Xu * And Chongshen Guo *,Bin Yang,Qun Zhang,‡ Chuanqi Song,Wei Guo,Chunyu Yang,Weicheng Huang,Fei Wang,Yan Gao
DOI:10.1039/c8nr08771g
An innovative sensor for hydroxylamine determination: Using molybdenum hybrid zeolitic imidazolate frameworkeconducting polymer composite as electrocatalyst
A novel composite material, hybrid zeolitic imidazolate framework (HZIF)econducting poly(3,4-
ethylenedioxythiophene) (PEDOT) has been fabricated on carbon cloth electrode (CCE) by microwaveassisted crystallization, followed by drop-coating and vapor deposition procedures. Specifically, the HZIF inserted by molybdenum (HZIF-Mo) is entitled to intrinsic catalytic activity towards amine molecules, which is firstly integrated with the conductive and catalytic PEDOT as an enhanced electrochemical sensor for hydroxylamine. Detection is performed by amperometric method, and the composite sensor (HZIF-Mo/PEDOT/CCE) shows a low detection limit of 0.04 mM(S/N ¼ 3) in the linear range of 0.1e692.2 mM, along with superior anti-interference ability, reproducibility (RSD ¼ 4.43%) and outstanding performance in real samples. As noticed, the hydroxylamine catalytic process combines the advantages of the alkaline-stable HZIF-Mo containing ample catalytic sites and high surface area and the mesoporous PEDOT reining in outstanding conductivity and redox capability, thereby imparting amplified electrochemical
signals. This work undertakes an opening to expand MOF-based composites for versatile
sensing applications.
期刊:
Electrochimica Acta
2019
作者:
Fengyu Qu*,Songjie Fan,Wei Guo,Cheng Jiang,Huiming Lin,Feng Zhang,Cuiyuan Liang
DOI:10.1016/j.electacta.2019.134945
Construction of Z-scheme MoSe2/CdSe hollow nanostructure with enhanced full spectrum photocatalytic activity
For better use of solar energy, the development of full-spectrum photocatalysts has attracted most attentions. In this research, uniform hollow MoSe2/CdSe nanospheres (250 nm) were prepared by one-pot solvothermal strategy. It is the first time to synthesize hollow MoSe2 based nanostructure without any template/surfactant assistance. By varying reaction time, the formation mechanism was investigated, illuminating that the novel hollow structure is derived from the Kirkendall Effect. Both experimental and density functional theory (DFT) calculations reveal the Z-scheme mechanism of the charge transfer in the heterostructure. The hollow MoSe2/CdSe nanospheres (MC2) possess the remarkable photocatalytic activity in degradation of Cr(VI) (125 mg g−1, simulated sunlight), owing to the high harvest of full spectrum, porous hollow structure and effective charge separation/transfer. Furthermore, the photocatalytic process was further studied in detail, showing that the Langmuir single-layer adsorption behavior, low pH value condition, and thermal effect also benefit to the high photoreduction performance. Benefiting from the Z-scheme mechanism, the high redox activity make sure the water splitting capacity of MC2 (7120.0 and 348.0 μmol h−1 g−1 of H2 and O2 evolution) under simulated sunlight irradiation and its AQY for H2 evolution at 670 nm reaches up to 27.2% (50 mg MC2).
期刊:
Applied Catalysis B: Environmental
2019
作者:
Fengyu Qu*,...,Huiming Lin,Wei Guo,Feng Zhang,Zhe Chen,Jingxiang Zhao,Ying Wang
DOI:10.1016/j.apcatb.2018.11.033
Co2.67S4-Based Photothermal Membrane with High Mechanical Properties for Efficient Solar Water Evaporation and Thermal Antibacterial
The lack of freshwater resources, or the freshwater crisis, is an important
issue in the resource field. One potential green and sustainable method to solve this
problem is to implement solar energy-driven water evaporation to collect freshwater.
Capitalizing on the low cost, high production yield, and simplified fabrication process
properties of nonstoichiometric Co2.67S4 nanoparticles, we strategically designed and
synthesized a Co2.67S4-deposited Teflon (PTFE) membrane for realizing efficient solar
water evaporation and photothermal antibacterial properties under light irradiation.
Compared with previously reported cellulose acetate and poly(vinylidene fluoride)
membranes, the PTFE membrane displayed significantly enhanced mechanical properties.
Additionally, a Co2.67S4-deposited PTFE membrane with a hydrophobic treatment
(termed as the Final-PTFE membrane) exhibited excellent durability. The light-to-heat
conversion efficiency (η) of water evaporation reached a value of 82% for our as-prepared
Final-PTFE membrane under two sun irradiation conditions. Moreover, the antibacterial
mechanism observed by scanning electron microscopy was attributed to the thermal effect, which damaged the cell wall of
bacteria. Our work highlights the great potentials of the Final-PTFE membrane as a versatile system for implementing solar
energy-driven photothermal water evaporation and water purification.
期刊:
ACS Appl. Mater. Interfaces
2019
作者:
Fengyu Qu*,Tianyue Ma,Haixia Liu,...,Wei Guo,Qingzhu Yang,Le Zhao
DOI:10.1021/acsami.9b04452
CoWO4-x-based nanoplatform for multimode imaging and enhanced photothermal/photodynamic therapy
Although phototherapy has received widespread attention in recent years due to its high efficiency, low invasiveness, and minor side effects, there are still few studies on the relationship between phototherapy and immunotherapy. Therefore, non-stoichiometric CoWO4-x nanoparticles (NPs) were strategically designed and prepared, as these can simultaneously generate hyperthermia and reactive oxygen species (ROS) under near-infrared laser irradiation, illustrating that they can be used to realize photothermal therapy (PTT) and photodynamic therapy (PDT) on tumors. CoWO4-x NPs not only have strong near-infrared absorption, outstanding biocompatibility, and excellent photothermal stability but they also can be used as photoacoustic (PA) and Computer Tomography (CT) contrast agents for working with tumors. In particular, the relationships between phototherapy, immunogenic cell death (ICD) and immunoresistance are here discussed in depth, and enhanced phototherapy was achieved for the first time by injecting etoposide and ML385, which are two typical inhibitors for HSP60 and NRF2, respectively. Furthermore, the biocompatibility of materials in vivo was demonstrated through a variety of cell experiments, changes in mouse body weight, and histological analyses. Our work highlights the great potentials of non-stoichiometric CoWO4-x NPs as a kind of multifunctional therapeutic agent for implementing enhanced phototherapy in breast cancer by reducing the immunoresistance of HSP60 and NRF2 toward PTT and PDT.
期刊:
Chemical Engineering Journal
2019
作者:
Fengyu Qu*,Jingyao Yu,Ruiwen Wang*,Na Xu,Le Zhao,Tianyue Ma,Jingxiang Zhao,Feng Zhang,Huiming Lin,Wei Guo,Qingzhu Yang,Haixia Liu
DOI:10.1016/j.cej.2019.123979
Surface-engineered vanadium nitride nanosheets for an imaging-guided photothermal/
photodynamic platform of cancer treatment
Of the many strategies for precise tumor treatment, near-infrared (NIR) light-activated “one-for-all” theranostic modality with real-time diagnosis and therapy has attracted extensive attention from researchers. Herein, a brand-new theranostic nanoplatform was established on versatile vanadium nitride (VN) nanosheets, which show significant NIR optical absorption, and resultant photothermal effect and reactive oxygen species activity under NIR excitation, thereby realizing the synergistic action of photothermal/photodynamic co-therapy. As expected, systematic in vitro and in vivo antitumor evaluations demonstrated efficient cancer cell killing and solid tumor removal without recurrence. Meanwhile, the surface modification of VN nanosheets with poly(allylamine hydrochloride) and bovine serum albumin enhanced the biocompatibility of VN and made it more suitable for in vivo delivery. Moreover, VN has been ascertained as a potential photoacoustic imaging contrast for in vivo tumor depiction. Thus, this work highlights the potential of VN nanosheets as a single-component theranostic nanoplatform.
期刊:
Nanoscale
2019
作者:
* Xiaojun Han * And Chongshen Guo *,Mingxing Ren,Qinmin Pan,Yaodong Chen,Zizuo Li,Wei Guo,Yan Gao,Huahai Yu,Chunyu Yang
DOI:10.1039/C8NR08269C
Bismuth Ferrite-Based Nanoplatform Design: An Ablation Mechanism Study of Solid Tumor and NIR-Triggered
Photothermal/Photodynamic Combination Cancer Therapy
Although nanomaterial-mediated phototherapy, in particular photothermal
therapy (PTT) and photodynamic therapy (PDT), is extensively investigated in
recent years, the ablation mechanism, evolution, and rehabilitation process
of in vivo solid tumor after phototherapy are rarely explored yet and remain a
terra incognita. Herein, a kind of bismuth ferrite nanoparticles (abbreviated as
BFO NPs) are strategically designed and synthesized with a desirable size and
bioactivity as a brand-new phototherapeutic agent for the phototherapy, which
are of strong near infrared (NIR) absorbance, excellent biocompatibility, and
outstanding photophysical activity for the hyperthemia and reactive oxygen
species generation. Resultantly, BFO NPs can realize simultaneous PTT/PDT
synergistic therapy outcome against cancer cells and solid tumor under NIR
laser irradiation. Meanwhile, for the first time, more attentions are paid to
demonstrate ablation mechanism and evolution process of in vivo solid tumor
after phototherapy by B-mode ultrasonography/magnetic resonance imaging
as well as histopathological analysis, all of which verify a series of physiological
processes, being in order of necrosis of parenchymal cells, in situ tissue
disintegration, liquefaction, and finally encapsulation process.
期刊:
Advanced Functional Materials
2018
作者:
* And Chongshen Guo*,Xiaojun Han,* Nannan Zheng,Qun Zhang,‡ Chuanqi Song,Yan Gao,Wei Guo,Yaodong Chen,Chunyu Yang
DOI:10.1002/adfm.201706827
Multifunctional Bismuth Nanoparticles as Theranostic Agent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy
“One-for-all” multifunctional theranostic agents are highly demanded in
biomedical fields. However, their design and fabrication still face enormous challenges.
Herein, we strategically design and fabricate 1,2-dilauroyl-sn-glycero-3-phosphocholinemodified
(DLPC-modified) bismuth nanoparticles (denoted as Bi@DLPC NPs) with
desirable size of 47 ± 3 nm as a theranostic agent for photoacoustic (PA) and X-ray
computed tomography (CT) imaging guided photothermal therapy (PTT) in response
to near-infrared (NIR) laser irradiation. Bi@DLPC NPs possess the excellent
photothermal conversion efficiency of 35% and PA/CT imaging properties, which
are attributed to the strong NIR absorption and high atomic number (83) of bismuth
element. Moreover, it is demonstrated that Bi@DLPC NPs are effectively accumulated
in the tumor region because of the enhanced permeability and retention (EPR) effect.
With the PTT, the growth of cancer cells (MDA-MB-231 cells) can be remarkably
ablated in vitro and in vivo; meanwhile no obvious damage and noticeable toxicity are
detected to major organs. The antitumor mechanism of Bi@DLPC NPs is attributable
to the mitochondrial dysfunction and change of cell membrane permeability of MDA-MB-231 cells caused by photothermal effects upon laser irradiation. On the basis of their high stability and excellent biocompatibility, Bi@DLPC NPs have great potential for the treatment of various types of tumors.
期刊:
ACS Applied Nano Materials
2018
作者:
* And Xiaojun Han*,Shaoqin Liu,Xiaole Zhao,Wei Guo,Chongshen Guo,Chunyu Yang
DOI:10.1021/acsanm.7b00255
Hydrophobic Cu12Sb4S13-deposited photothermal film for interfacial water evaporation and thermal
antibacterial activity
Hydrophobic Cu12Sb4S13 nanoparticles with strong and full-spectrum
photoabsorption in the range of 200–2500 nm were fabricated
and deposited on cellulose acetate (CA) membrane to form a photothermal
film, which could realize photothermal heating for vapor
generation and thermodestruction of pathogenic bacteria of E. coli
O157:H7 simultaneously under light irradiation.
期刊:
New Journal of Chemistry
2018
作者:
Chongshen Guo,Mei Yan,Weicheng Huang,Di An,Qun Zhang,Chunyu Yang,Yan Gao,Wei Guo,‡ Tianchan Li,‡ Chuanqi Song
DOI:10.1039/c7nj04545j
Selective capture and rapid identification of E. coli O157:H7 by carbon nanotube multilayer biosensors
and microfluidic chip-based LAMP
We describe a sensitive approach for visual and point-of-care detection of E. coli O157:H7 and its toxic gene by combining carbon nanotube (CNT) multilayer biosensors and microfluidic chip-based loop-mediated isothermal amplification (LAMP). The anti-E. coli O157:H7 functionalized CNT multilayer biosensor can selectively capture the target bacterium E. coli O157:H7 in complex samples. After culturing, the captured bacteria can be released on demand by cleavage of the anti-E. coli O157:H7 antibody–bacteria interaction. The DNA concentration of the released bacteria was subsequently analyzed with microfluidic chip-based LAMP. After systematic optimization of capturing and detecting conditions, the proposed sensing platform was capable of detecting concentrations as low as 1 CFU mL1 without complicated instrumentation, this is much more sensitive than previous reported methods. The distinct advantages of the proposed sensing platform, such as high specificity, low cost, good reproducibility and the ability of regenerating, make it a potential platform for detecting E. coli O157:H7 in related food safety and clinical diagnosis.
期刊:
RSC Advances
2017
作者:
Mei Yan* And Shaoqin Liu *,Jing Zhao,Hongxi Gu,Wei Guo,Fanjiao Zhu,‡ Tianchan Li
DOI:10.1039/c7ra04583b
MoO3−x quantum dots for photoacoustic imaging guided photothermal/photodynamic cancer treatment
A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because of the ability to integrate diagnostics and therapies together, thus enhancing accuracy and visualization during the treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined cancer treatment just via a single material, MoO3−x quantum dots (QDs). Due to their strong NIR harvesting ability, MoO3−x QDs can convert incident light into hyperthermia and sensitize the formation of singlet oxygen synchronously as evidenced by in vitro assay, hence, they can behave as both PT and PD agents effectively and act as a “dual-punch” to cancer cells. In a further study, elimination of solid tumors from HeLa-tumor bearing mice could be achieved in a MoO3−x QD mediated phototherapeutic group without obvious lesions to the major organs. In addition, the desired PT effect also makes MoO3−x QDs an exogenous PA contrast agent for in vivo live-imaging to depict tumors. Compared with previously reported theranostic systems that put several components into one system, our multifunctional agent of MoO3−x QDs is exempt from unpredictable mutual interference between components and ease of leakage of virtual components from the composited system.
期刊:
Nanoscale
2017
作者:
...,Shaoqin Liu,Mei Yana,Fei Wang,* Nannan Zheng,† Jianzhe Sun,Chongshen Guo,Wei Guo,‡ Dandan Ding
DOI:10.1039/C6NR09046J
TiO2−x Based Nanoplatform for Bimodal Cancer Imaging and NIRTriggered
Chem/Photodynamic/Photothermal Combination Therapy
Integration of cancer diagnosis and treatment, namely theranostics, is an important issue in the biomedical field. Benefiting from an excellent photothermal effect, ROS generation ability, and the desired mesoporous structure of the TiO2–x matrix, we strategically designed and fabricated a TiO2–x based theranostic system for realizing fluorescence/photoacoustic tomography (PAT) bimodal imaging guided triple therapy for photothemal/photodynamic/chemotherapy in this work. Nonstoichiometric TiO2–x nanospheres are excellent near-infrared absorptive material, which takes on both photosensitizer and photothermal agent roles in implementing PDT/PTT combination therapy and PAT imaging. Moreover, the mesoporous structure of TiO2–x also allowed drug loading, and the polydopamine sealing layer enabled it to induce NIR/pH-triggered drug controlled release. Resultantly, both the in vitro and in vivo experiment manifested the remarkable tumor inhibition and tumor imaging effects by the TiO2–x based theranostic system. The antitumor mechanism was attributable to a synergistic therapeutic effect (combination index = 0.318) of DOX-induced DNA damage, and PDT/PTT caused mitochondrial dysfunction and a change in the cell membrane permeability. Innovatively, the B-mode ultrasonography was adopted to monitor the rehabilitation process at the solid tumor site after treatment, which observed a liquefaction necrosis process.
期刊:
Chemistry of Materials
2017
作者:
And Shaoqin Liu*,Chongshen Guo,‡ Chuanqi Song,‡ Dandan Ding,Fei Wang,...,Wei Guo
DOI:10.1021/acs.chemmater.7b03241
CsxWO3 Nanorods Coated with Polyelectrolyte Multilayers as a Multifunctional Nanomaterial for Bimodal Imaging- Guided Photothermal/Photodynamic Cancer Treatment
CsxWO3 nanorods coated with polyelectrolyte multilayers are developed as “four‐in‐one” multifunctional nanomaterials with significant potential for computed tomography/photoacoustic tomography bimodal imaging‐guided photothermal/photodynamic cancer treatment.
期刊:
Advanced Materials
2017
作者:
And Shaoqin Liu*,Tiedong Sun,* Nannan Zheng,Chongshen Guo,Wei Guo
DOI:10.1002/adma.201604157
Multifunctional Theranostic Agent of Cu2(OH)PO4 Quantum Dots for Photoacoustic Image-Guided Photothermal/Photodynamic Combination Cancer Therapy
Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy and higher treatment accuracy. Compared to complicated systems with multiple components, using a single material for this multifunctional purpose is preferable. In this work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu2(OH)PO4 quantum dots [denoted as Cu2(OH)PO4@PAA QDs], which exhibit a strong near-infrared photoabsorption ability. As a result, an excellent photothermal conversion ability and the photoactivated formation of reactive oxygen species could be realized upon NIR irradiation, concurrently meeting the basic requirements for photothermal and photodynamic therapies. Moreover, phototherapeutic investigations on both cervical cancer cells in vitro and solid tumors of an in vivo mice model illustrated the effective antitumor effects of Cu2(OH)PO4@PAA upon 1064-nm laser irradiation, with no detectable lesions in major organs during treatment. Meanwhile, Cu2(OH)PO4@PAA is also an exogenous contrast for photoacoustic tomography (PAT) imaging to depict tumors under NIR irradiation. In brief, the Cu2(OH)PO4@PAA QDs prepared in this work are expected to serve as a multifunctional theranostic platform.
期刊:
ACS Applied Materials & Interfaces
2017
作者:
And Shaoqin Liu*,* Nannan Zheng,† Jianzhe Sun,Fei Wang,‡ Tianchan Li,‡ Dandan Ding,Chongshen Guo,‡ Zhenyu Qiu,...,Wei Guo
DOI:10.1021/acsami.6b15703
Urchin-like tungsten suboxide for photoacoustic imaging-guided photothermal and photodynamic
cancer combination therapy
Being an encouraging approach with high selectivity and minor side-effects, imaging-guided phototherapy for cancer treatment has attracted lots of research interest. Wherein particularly important is the development of a novel agent that favors cancer imaging and phototherapy in one. In this study, urchin-like tungsten suboxide nanomaterials (WOs) were synthesized for photothermal (PT) and photodynamic (PD) combined cancer treatment, as well as photoacoustic (PA) imaging to depict tumors. On the basis of strong photoabsorption in the near-infrared (NIR) region, the WOs exhibit high photothermal conversion and singlet-oxygen generation efficiency, and thus can achieve dual effects of PT and PD therapies, resulting in severe cancer cell death and apoptosis as proved by in vitro assays. Further in vivo experiments with HeLa tumor-bearing nude mice reveal that WOs have an effective photoablation outcome for malignant tumors
under 1064 nm NIR light irradiation, whereas there is no obvious systematical toxicity for major organs and no hematological disorders. Finally, WOs could also function as excellent PA agents in consideration of their rapid and significant PA signal enhancement in the tumor region. Altogether, our research work demonstrates the potential of WOs as a multifunctional nanoagent for PA imaging-guided PT and PD cancer therapy.
期刊:
New Journal of Chemistry
2017
作者:
Chongshen Guo* And Shaoqin Liu*,Mei Yan,Yan Gao,Qun Zhang,‡ Dandan Ding,Wei Guo,‡ Chuanqi Song,Fei Wang
DOI:10.1039/c7nj03078a
MoS2-Based Multipurpose Theranostic Nanoplatform: Realizing Dual-Imaging-Guided Combination Phototherapy to Eliminate Solid Tumor via a Liquefaction Necrosis Process
Theranostics that combines the disease diagnosis with treatment is of promising application in the foreground of personalized medicine to achieve a precise treatment with minimum side effects. In this work, we strategically designed a “four-in-one” theranostic nanoplatform for realizing the desired imaging-guided phototherapy, in which functions of fluorescent imaging, photoacoustic imaging tomography (PAT), photothermal therapy (PTT) and photodynamic therapy (PDT) were implemented by bioconjugated MoS2 nanosheets. The protagonist of MoS2 is a light-harvesting material in the near-infrared (NIR) region, which would produce localized hyperthermia at the tumor site to trigger the photothermal therapy effect for the tumor ablation as well as a PAT signal to depict the tumor concurrently upon NIR excitation. To our surprise, MoS2 has been found to be a photosensitizer for the cancer PDT treatment as well. Moreover, bovine serum albumin (BSA) decoration on MoS2 has been made to improve biocompatibility, which also allowed further conjugation with a fluorescent molecule of Cy5.5 to endow the overall nanoplatform with fluorescence imaging and monitoring features. On the basis of the above characters, great successes in cancer imaging and tumor photoablation were achieved in both in vitro and in vivo experiments. Innovatively, B-ultrasonography and MRI imaging were employed to monitor the elimination process of solid tumor after treatment, which clearly revealed a liquefaction necrosis process for rehabilitation. In short, MoS2 represents a nanoplatform of this work and manifested huge advantages in the cancer theranostics.
期刊:
Journal of Materials Chemistry B
2017
作者:
Shaoqin Liu* And Chongshen Guo *,Mei Yan,Wei Guo,Yan Gao,‡ Dandan Ding,Fei Wang,Chunyu Yang,‡ Chuanqi Song
DOI:10.1039/C7TB02648J
Target Delivery of a Novel Antitumor Organoplatinum(IV) Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo
An inactive organoplatinum(IV)‐substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of PtIV‐PW11 with DSPE‐PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such PtIV‐PW11‐DSPE‐PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin.
期刊:
Advacned Materials
2016
作者:
* And Qiong Wu *,Shaoqin Liu,Hongxi Gu,Wei Guo,Geng Qin,Mei Yan,Wei Cui,Tiedong Sun
DOI:10.1002/adma.201601778
Fabrication of AgBr nanomaterials as excellent antibacterial agents
Nanoparticles of a sparingly soluble silver salt of AgBr with an appropriate solubility product and high photocatalytic response ought to be promising candidates with superior and multifunctional antibacterial effects, but they have received relatively little scientific attention until now. In the present study, the antibacterial activities of AgBr nanocubes and their derivative Ag@AgBr against E. coli were investigated both in the dark and under visible light irradiation. Benefiting from the “dual-punch” of eluted Ag+-induced disturbance of bio-function and nanocube-induced contact damage to cellular membranes, the 100 nm well-defined AgBr nanocubes realized outstanding antibacterial properties, with MIC (minimal inhibition concentration) and MBC (minimum bactericidal concentration) values as low as 0.1 μg ml−1 and 0.4 μg ml−1, respectively. Ag decoration on the surface of AgBr seems to deteriorate the antibacterial properties, as the MIC and MBC values increased to 0.75 μg ml−1 and 1 μg ml−1 in the dark for the sample of Ag@AgBr, but it exhibits better photocatalytic inhibition of E. coli growth than pure AgBr by virtue of the enhanced light-harvesting by the LSPR effect from the Ag component. Thus, the encouraging results shown in this study indicate the great potential of AgBr nanomaterial to serve as an antibacterial candidate with high antibacterial activity.
期刊:
RSC Advances
2015
作者:
Chongshen Guo* And Shaoqin Liu*,Wei Guo,Zhouzhou Liu
DOI:10.1039/C5RA12575H
Fe3O4@mSiO2 core–shell nanocomposite capped with disulfide gatekeepers for enzyme-sensitive
controlled release of anti-cancer drugs
Multifunctional nanocarriers based on the magnetic Fe3O4 nanoparticle core and bis-(3-carboxy-4-
hydroxy phenyl) disulfide (R–S–S–R1) modified mesoporous silica shell (Fe3O4@mSiO2@R–S–S–R1) were
synthesized for cancer treatment through passive targeting and enzyme-sensitive drug release. Anticancer
drug doxorubicin (DOX) was used as the model cargo to reveal the release behavior of the
system. The drug loading system (DOX–Fe3O4@mSiO2@R–S–S–R1) retains the drug until it reaches the
tumor tissue where glutathione reductase (GSH) can degrade the disulfide bonds and release the drug.
Furthermore, the grafting amount of R–S–S–R1 can be used to adjust the release performance. All the
release behaviors fit the Higuchi model very well and the release kinetics are predominated by disulfide
bond degradation and mesoporous structure. With good bioactivity and targeted release performance,
the system could play an important role in the development of intracellular delivery nanodevices for
cancer therapy.
期刊:
Journal of Materials Chemistry B
2015
作者:
Huiming Lin,Gang Guo,Ting Zhang,Na An,Liru Cui,Wei Guo,Chunyu Yang
DOI:10.1039/c4tb01788a
Enzyme-sensitive magnetic core–shell nanocomposites for triggered drug release
Fe3O4@mSiO2 (magnetic Fe3O4 core coated by a mesoporous silica shell) nanoparticles were successfully synthesized as a carrier. The anti-cancer drug doxorubicin (DOX) and chlorambucil (Chl) were used as the model cargo. After the drug-loading, a sodium hyaluronic acid (HA) cross-linked gel was adopted to coat the outside of the Fe3O4@mSiO2 nanoparticles as a layer (named as drug–Fe3O4@mSiO2–HA) to prevent drug pervasion. The detailed release kinetics were investigated, revealing the sensitive release triggered by hyaluronidase (HAase), a major enzyme which is rich in the tumor microenvironment, which can degrade the HA shell to induce the enzyme sensitive drug release. Moreover, there are some HA receptors in many tumor areas, associating with magnetic targets to further ensure the specific targeted drug delivery. With these improved performances, these smart multifunctional nanocomposites are expected to possess potential applications in the biopharmaceutical for cancer therapy.
期刊:
RSC Advances
2015
作者:
Huiming Lin* And Fengyu Qu*,Yuhua Chen,Ruihan Tong,Ting Zhang,Liru Cui,Na An,Wei Guo,Chunyu Yang
DOI:10.1039/c5ra15026d
P(EO-co-LLA) functionalized Fe3O4@mSiO2 nanocomposites for thermo/pH responsive drug controlled release and hyperthermia
The Fe3O4@mSiO2 nanocarrier that consisted of a magnetic Fe3O4 nanoparticle core and a mesoporous silica (mSiO2) shell was synthesized. It shows a uniform sphere morphology about 65 nm in diameter. Considering the magnetic hyperthermia of Fe3O4 under an alternating magnetic field (AMF), a thermosensitive polymer, poly[(ethylene glycol)-co-(L-lactide)] (P(EO-co-LLA)), was used as “gatekeeper” coating outside Fe3O4@mSiO2 to regulate the drug release behavior. The design of the nanocarrier was expected to block off the pores at low temperature and to reopen them at high temperature reversibly. The obtained hybrid nanocomposites were capable of loading the anti-cancer drug doxorubicin (DOX) and controlled drug release behavior trigged by the hyperthermia of Fe3O4 under AMF. Besides, the nanocarriers also show pH-sensitive drug release based on the slight differences between the tumor (weakly acid) and the normal tissue (weakly alkaline). What’s more, the chemotherapy of DOX combined with magnetic hyperthermia can improve the cytotoxicity obviously. On the basis of the high stability and excellent controlled release performance, the multifunctional nanocarriers exhibit potential applications in targeted-control drug release and hyperthermia for cancer treatment.
期刊:
Dalton Transactions
2014
作者:
B And Fengyu Qu*a,A Huiming Lin*a,A Chunyu Yang,Wei Guo
DOI:10.1039/c4dt02441a
pH-responsive controlled-release system based on mesoporous bioglass materials capped with mineralized hydroxyapatite
A controlled release system with pH-responsive ability has been presented. Mesoporous bioglass (MBG) was used as the drug carrier and a spontaneous mineralization method was adopted to cap the pores of the carrier with hydroxyapatite (HAp) and to restrict the drug release. It is a simple and green method to realize the ingenious pH-sensitive controlled release. The model drug, metformin hydrochloride (MH), was loaded simultaneously with the mineralization process. Due to the degradation of HAp at acid environments, the system shows well pH-sensitive drug release ability. The release kinetics can be easily adjusted by the mineralization time and the ion concentration of media. The system is recommended as a promising candidate as a pH-sensitive vehicle for drug controlled release to low pH tissues, such as inflammatory sites and tumors.
期刊:
Materials Science and Engineering C
2014
作者:
Fengyu Qu*,Huiming Lin,Kun Cai,Di Xiang,Liru Cui,Wei Guo,Chunyu Yang
DOI:10.1016/j.msec.2013.12.006
A novel pH-responsive controlled release system based on mesoporous silica coated with hydroxyapatite
With well bioactive and nontoxic, hydroxyapatite
(HAp) was employed to seal the nanopores of mesoporous
silica (MCM-41) to realize the pH-responsive
controlled release. First, MCM-41 was modified with cationic
polymer, poly-(diallyldimethylammoniumchloride)
(PA). And after the addition of Ca2?/PO4
3-, HAp precipitation
can take place based on the cationic sites derived
from PA. It is a simple and effective way to obtain HAp
coating MCM-41 system (MHAs). The structure of the
system was characterized by X-ray diffraction, scanning
electron microscope, transmission electron microscope, N2
adsorption–desorption and so on. Metformin hydrochloride
was used as the model drug, and the drug release performance
and the release kinetics of the system were investigated
in detail. Because of the degradation of HAp under
acid condition, the drug loading MHAs showed a well pHsensitive
controlled release behavior. From above investigation,
MHAs is a promising platform to construct a pHresponsive
controlled drug delivery system, especially for
some low pH tissues, such as inflammatory and tumor.
期刊:
Journal of Sol-Gel Science and Technology
2014
作者:
...,Fengyu Qu*,Ting Zhang,Dan Zhou,Di Xiang,Wei Guo,Huiming Lin,Liru Cui
DOI:10.1007/s10971-014-3419-0
pH-Responsive Magnetic Core−Shell Nanocomposites for Drug Delivery
Polymer-modified nanoparticles, which can load anticancer
drugs such as doxorubicin (DOX), showing the release in response to a
specific trigger, have been paid much attention in cancer therapy. In our
study, a pH-sensitive drug-delivery system consisting of Fe3O4@mSiO2
core−shell nanocomposite (about 65 nm) and a β-thiopropionatepoly(
ethylene glycol) “gatekeeper” (P2) has been successfully synthesized
as a drug carrier (Fe3O4@mSiO2@P2). Because of the hydrolysis of the β-
thiopropionate linker under mildly acidic conditions, Fe3O4@mSiO2@P2
shows a pH-sensitive release performance based on the slight difference
between a tumor (weakly acid) and normal tissue (weakly alkaline). And
before reaching the tumor site, the drug-delivery system shows good drug
retention. Notably, the nanocomposites are quickly taken up by HeLa cells
due to their small particle size and the poly(ethylene glycol) modification,
which is significant for increasing the drug efficiency as well as the cancer
therapy of the drug vehicles. The excellent biocompatibility and selective release performance of the nanocomposites combined
with the magnetic targeted ability are expected to be promising in the potential application of cancer treatment.
期刊:
Langmuir
2014
作者:
* And Fengyu Qu*,Huiming Lin,Ting Zhang,Na An,Liru Cui,Wei Guo,Chunyu Yang
DOI:10.1021/la501833u
Synthesis of pH-responsive mesoporous silica nanotubes for controlled release
A novel mesoporous silica tubes (MMT) which
possessed pH-sensitive controlled release ability had been
fabricated and synthesized by using carbon nanotubes
(CNTs) as template. The sample replicated the morphologies
of the CNTs successfully. The Brunauer–Emmett–
Teller surface area of the materials can reach 1,017 m2 g-1
with the pore size of 3.8 nm. As a model drug, metformin
HCl was applied to study the drug loading and control
release ability of the materials. MMT possesses higher drug
loading ratio (36 %) than that of MCM-41 (27.5 %). The
release kinetics were studied in simulated gastric fluid
(pH = 1.2) and in simulated proximal intestine fluid
(pH = 7. 4), respectively. The result shows that the
delivery systems exhibit well pH-sensitive control release
ability and the as-synthesized materials have potential
application in biomedical field.
期刊:
Journal of Sol-Gel Science and Technology
2014
作者:
Fengyu Qu*,Wei Guo,Di Xiang,Chunhui Bian,Xiaofeng Li,Rong Xing,Huiming Lin,Jie Ma
DOI:10.1007/s10971-013-3228-x
Simple way to obtain pH-sensitive drug release from functional mesoporous silica materials
A novel pH-sensitive drug release system has been synthesised by functional mesoporous silica materials. SBA-15,
calcium modified SBA-15 (Ca-SBA-15) and phosphate modified SBA-15 (PO4-SBA-15) were synthesised using solvent
evaporation method. It is a simple and feasible way to prepare the doping mesoporous silica materials. They show the large
surface are, high pore volume and uniform pore size. Metformin hydrochloride was used as the model drug, and the control
release behaviour was investigated. The functional mesoporous silica materials show the pH sensitive drug release behaviour
because of the adjustable interaction between the drug molecule and the host.
期刊:
IET Nanobiotechnology
2013
作者:
Fengyu Qu*,Jingjie Jiang,Liru Cui,Jie Ma,Wei Guo,Huiming Lin,Di Xiang
DOI:10.1049/iet-nbt.2013.0019
A pH-sensitive controlled dual-drug release from meso-macroporous silica/multilayer-polyelectrolytes coated SBA-15 composites
A novel dual-drug delivery system based on mesoporous-macroporous silica/polyelectrolytes-SBA-15 has been synthesized. The structure and composition of these materials were characterized by powder X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and N2 adsorption–desorption measurements. In this system,
water-soluble metformin hydrochloride and fat-soluble ibuprofen were used as model drugs to study the controlled release behavior. The pH-controlled release of individual drugs was
obtained by the primary release of metformin hydrochloride from polyelectrolytes-SBA-15 in acid condition and the predominant release of ibuprofen from MMC in alkaline environment. The results show that the polyelectrolytes-SBA-15/mesoporous-macroporous silica can be used as dual-drug release system and the individual drug can be controlled release
with the change of pH value of the environment.
期刊:
Journal of Sol-Gel Science and Technology
2013
作者:
Huiming Lin,Wei Guo,Yan Dong,Jingjie Jiang,Fengyu Qu*,Qumei Jin
DOI:10.1007/s10971-013-3033-6
One-pot synthesis of magnetic, macro/mesoporous bioactive glasses for bone tissue engineering
Magnetic and macro/mesoporous bioactive glasses were synthesized by a one-pot method via
a handy salt leaching technique. It was identified to be an effective and simple synthetic
strategy. The non-ionic triblock copolymer, poly(ethylene glycol)-block-poly(propylene
glycol)-block-poly(ethylene glycol) (P123), was used as the structure directing agent for
mesoporous structure but also as the reductant to reduce the iron source into magnetic iron
oxide. The prepared materials exhibited excellent super-paramagnetic property with
interconnected macroporous (200–300μm) and mesoporous (3.4 nm) structure. Furthermore,
their outstanding drug storage/release properties and rapid (5) induction of hydroxyapatite
growth ability were investigated after immersing in simulated body fluid solution at 37 C.
Notably, the biocompatibility assessment confirmed that the materials obtained presented
good biocompatibility and enhanced adherence of HeLa cells. Herein, the novel materials are
expected to have potential application for bone tissue engineering.
期刊:
Science and Technology of Advanced Materials
2013
作者:
Yingxue Jin And Fengyu Qu,Xiaodan Wu,Wei Guo,Xiao Han,Jingjie Jiang,...,Huiming Lin,Dan Wang
DOI:10.1088/1468-6996/14/2/025004
Long-term controlled release of dual drugs from MBG/PLGA composite microspheres
In this study, a long-term controlled drug release
system was designed based on mesoporous bioactive glass
coated with poly(lactide-co-glycolide) (MBG/PLGA). In this
system ibuprofen (Ibu) and egg white protein were used as the
model drugs. Firstly, Ibu was loaded into MBG and MBG/
PLGA microspheres were formed after MBG/PLGA. Then
the egg white protein was adsorbed outside of the MBG/
PLGA because of the interaction between the hydroxyapatite
and the protein. The drug release tests indicate that Ibu and
egg white protein can release from the long-term controlled
dual drugs system at the same time. Notably, the release time
of Ibu can reach 18 days, and the release time of egg white
protein can reach to 6 days due to the role of PLGA. The
release rate of Ibu is 49 % of loading rate (46 %), while the
release rate of egg white protein is 47 % of adsorption value
(184 lg/mg), indicating that the dual drug release system is
highly potential in the practical bone repair application.
期刊:
Journal of Sol-Gel Science and Technology
2013
作者:
Fengyu Qu*,Di Xiang,Jingjie Jiang,Huiming Lin,Jing Zhang,Wei Guo
DOI:10.1007/s10971-013-3130-6
An Enzyme-Responsive Controlled Release System of Mesoporous Silica Coated with Konjac Oligosaccharide
A simple and green method to fabricate an ingenious
enzyme-responsive drug controlled release system was presented.
Mesoporous silica material (mSiO2) 100 nm in size was used as the
host, and Konjac oligosaccharide (KOGC) was employed to seal
the nanopores of mSiO2 to inhibit the drug release. Rhodamine B
was used as the model cargo to reveal the release behavior of the
system. The KOGC-modified mSiO2 (mSiO2@KOGC) retains the
drug until it reaches the colonic environment where bacteria secrete
enzymes (β-mannanase) can degrade KOGC and make drug
release. The amount of KOGC and enzyme can be used to adjust
the release performance. And all the release behaviors fit the twostep
Higuchi model, which predominate by KOGC degradation and
mesoporous structure, respectively. With well bioactivity and
selectivity, the system has potential application as an oral medicine
carrier for treating intestinal disease.
期刊:
Langmuir
2013
作者:
* And Fengyu Qu*,Huiming Lin,Liru Cui,Chunyu Yang,Wei Guo
DOI:10.1021/la403494q
