More than 40 years ago, Vogal proposed the "error catastrophe" hypothesis to explain the phenomenone of aging.  Others have proposed "mutation catastrophe" hypothesis to further include the possible influence by mutation. These and other theories have connected stochastic errors in expression of genetic information with aging. We tried to futher explore this connection and identify key mediators underlying such connection, using phenotypic data of mutation rate and translational error rate, in combination of genotype of yeast strains.