联系我们
意见反馈

关注公众号

获得最新科研资讯

系统与进化基因组学实验室

简介 研究随机现象如何影响生物的功能与进化

分享到
实验室简介

 

实验室简介

        生命活动的本质是具有一定随机性的生化反应,由此产生的随机现象可以通过各种方式影响生物的功能与进化,并与人类健康具有深入的联系。我们从进化基因组与系统生物学的角度,分析生物活动各个层面的随机现象,并发展相关的研究方法和分析工具。

还没有发布内容

Genetic regulation of phenotypic heterogeneity

Isogenic cells could have vastly different phenotypes. Such phenotypic heterogeneity is stochastic in its nature, but is also highly regulated. Phenotypic heterogeneity ensures poulation survival in the face of extreme environments, but is also deleterious as it lowere the population-average fitness by driving some individuals away from the phenotypic optimum. It has also been implicated in antibiotic resistance bacteria or chemo-resistance of cancer cells. We aimed to identify genetic regulators of phenotypic heterogeneity using high-throughput phenotyping data.

Autonomous versus regulatory cellular development

Development, or differentiation/proliferation, could be autonomous or regulatory. The classic example of C. elegans development was generally considered an exception, whereas the development of most other animals are believed to be mostly regulatory. This conjecture was, however, never formally tested. We aimed to assess the autonomous/regulatory component of the development of animals by reconstruction of the developmental cell lineage tree.

The role of mutation, drift and selection in evolution of codon usage bias

18 of the amino acids were each encoded by more than one codon, but the synonymous codons were not used with equal frequency, a phenomenone known as the "codon usage bias". It is commonly accepted that the evolution of codon usage bias was underlied by mutation, drift and selection. We explored the relative contribution of chance (mutation and drift) and necessity (selection) in determining the codon usage bias of cells and genes.

访问量:462