Lu Lab - Protein Design

We design transmembrane proteins.

Programmable design of orthogonal protein heterodimers


Fig. 2

Protein–protein interaction specificity can be achieved using extensive and modular side-chain hydrogen-bond networks. We used the Crick generating equations to produce millions of four-helix backbones with varying degrees of supercoiling around a central axis, identified those acc...

Prof. David Baker shared his insights on de novo protein design with PNAS, talking about transmembrane protein design.


"If you want to build an airplane, you don’t start by modifying a bird; instead, you understand the first principles of aerodynamics and build flying machines from those principles. As we get closer to solving the protein folding problem, we can now design completely new proteins from ...







The coming of age of de novo protein design


There are 20200 possible amino-acid sequences for a 200-residue protein, of which the natural evolutionary process has sampled only an infinitesimal subset. De novo protein design explores the full sequence space, guided by the physical principles that underlie protein fold...

De novo Protein Design---Science's Breakthrough of the Year, 2016


Cover image expansion

"Designing new proteins from scratch has been a hit-or-miss activity. It’s easy enough to write any desired DNA code, but researchers have had no way of knowing how the novel strings of amino acids encoded by this DNA would fold into complex 3D shapes. That’s a problem, becau...

Three-dimensional structure of human γ-secretase


The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage. Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation of amylo...