Lu Lab - Protein Design

We design transmembrane proteins.

Keep Your Eyes on the Prize: A Life Connected with Science -------- By Ronald D. Vale

01.05.2019

"I feel that my greatest prize has been the privilege of a life connected with science. I have enjoyed innumerable discoveries, both my own and those of others, and I have met many kind and interesting people along the way. My best advice to young scientists is to keep your eyes on these pri...

Programmable design of orthogonal protein heterodimers

20.12.2018

Fig. 2

Protein–protein interaction specificity can be achieved using extensive and modular side-chain hydrogen-bond networks. We used the Crick generating equations to produce millions of four-helix backbones with varying degrees of supercoiling around a central axis, identified those acc...

Prof. David Baker shared his insights on de novo protein design with PNAS, talking about transmembrane protein design.

09.12.2018

"If you want to build an airplane, you don’t start by modifying a bird; instead, you understand the first principles of aerodynamics and build flying machines from those principles. As we get closer to solving the protein folding problem, we can now design completely new proteins from ...

新华社报道:科学家用计算机设计制造出跨膜蛋白质

03.03.2018

新华社华盛顿3月2日电(记者周舟)

       美国华盛顿大学一个科研团队借助计算机设计,制造出了跨膜蛋白质,它可像天然膜蛋白那样形成多蛋白复合体,可应用在疫苗设计等领域。

  膜蛋白是生物膜中所含的蛋白质,嵌在细胞和细胞器的膜中。有些膜蛋白的两端暴露于膜的内外表面,被称作跨膜蛋白质。它们可作为物质跨膜转运的通道,许多药物设计将其作为靶标。

  本次研究论文发表在最新一期《科学》杂志上。论文第一作者、华盛顿大学贝克实验室的卢培龙对新华社记者说,他们使用一种叫做“罗塞塔”的计算机程序,设计了能在膜环境中稳定...

The coming of age of de novo protein design

12.12.2016

There are 20200 possible amino-acid sequences for a 200-residue protein, of which the natural evolutionary process has sampled only an infinitesimal subset. De novo protein design explores the full sequence space, guided by the physical principles that underlie protein fold...

De novo Protein Design---Science's Breakthrough of the Year, 2016

12.12.2016

Cover image expansion

"Designing new proteins from scratch has been a hit-or-miss activity. It’s easy enough to write any desired DNA code, but researchers have had no way of knowing how the novel strings of amino acids encoded by this DNA would fold into complex 3D shapes. That’s a problem, becau...

Three-dimensional structure of human γ-secretase

14.08.2014

The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage. Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation of amylo...