Our ultimate goal is to understand how the brain controls numerous behaviors. With this goal in mind, we choose to focus on the circuit mechanisms controlling motor functions, which are easy to be quantified and interpreted. Specifically, we are interested in the cerebellar and brainstem neural circuits controlling fine motor movements. Using techniques including circuit tracing, circuit manipulations, in vivo recordings and customized behavior paradigms, we aim to characterize circuit mechanisms underlying normal motor functions and essential tremor, the most common movement disorder.
We have positions available for postdocs, graduate students, undergraduate students and technicians. We also welcome applicants from engineering backgrounds. If you are fascinated by the mystery of neuroscience, you will find our lab an inspiring environment. Please email the PI and explain why you are interested. We will arrange interviews ASAP for promising candidates.
1. Neural mechanisms of Essential Tremor
Holding a glass of milk, brushing teeth and tying shoe laces might all sound so simple tasks that one rarely even think about them. But for patients with essential tremor, all these life routines can become very challenging. Essential tremor is reported to be the most common movement disorder. It is estimated to affect 1% of the general population and its prevalence increases with age.
We aim to use mouse models to elucidate the neural circuit me...