Divergent Protosilylation and Protoborylation of Polar Enynes
Copper-catalyzed divergent conjugate protosilylation and protoborylation of polar enynes were developed. The corresponding β-boryldienoates and β-silyldienotes were obtained in moderate to good yields and with good stereoselectivity. In this protocol, novel cascade double protoborylation/protodeboronation processes of polar enynoates enabled access of the useful trisubstituted vinylboronates in up to 80% yield and with up to 98:2 Z/E ratio. Moreover, divergent transformations of the products thus obtained were also investigated.
期刊:
Organic Letters
2019
作者:
Teck-Peng Loh,Yun-He Xu,Jia-Hao Xie,Meng Zhao,Bing Jiang,Qi-Yan Xue,Fei-Fan Meng
DOI:10.1021/acs.orglett.9b00995
Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins
A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.
期刊:
The Journal of Organic Chemistry
2018
作者:
Teck-Peng Loh,Yun-He Xu,Bing Jiang,Qiu-Ju Liang
DOI:10.1021/acs.joc.8b00991
Copper-Catalyzed Dehydrogenative Diels–Alder Reaction
A practical and effective copper-catalyzed dehydrogenative Diels−Alder reaction of gem-diesters and ketone with dienes has been established. The active dienophiles were generated in situ via a radical-based dehydrogenation process, which reacted with a wide variety of dienes to afford various polysubstituted cyclohexene derivatives in good to excellent yields.
期刊:
Organic Letters
2018
作者:
Teck-Peng Loh,Yun-He Xu,Meng Zhao,Yu Han,Qiu-Ju Liang,Bing Jiang
DOI:10.1021/acs.orglett.8b01067
Chelation versus Non-Chelation Control in the Stereoselective Alkenyl sp2
C−H Bond Functionalization Reaction
期刊:
Angewandte Chemie International Edition
2017
作者:
Teck-Peng Loh,Yun-He Xu,Bing Jiang,Fei-Fan Meng,Chao Yang,Qiu-Ju Liang
DOI:10.1002/anie.201700559
Palladium-Catalyzed Direct Intramolecular C–N Bond Formation: Access to Multisubstituted Dihydropyrroles
A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.
期刊:
Organic Letters
2017
作者:
Teck-Peng Loh,Yun-He Xu,Qiu-Ju Liang,Fei-Fan Meng,Bing Jiang
DOI:10.1021/acs.orglett.7b00072
Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes
A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3‐conjugated diene structure.
期刊:
Angewandte Chemie International Edition
2017
作者:
Teck-Peng Loh,Yun-He Xu,Shu-Sen Li,Meng Zhao,Bing Jiang
DOI:10.1002/anie.201710601
B(C6F5)3: A New Class of Strong and Bulky Lewis Acid for Exo-Selective Intermolecular Diels–Alder Reactions of Unreactive Acyclic Dienes with α,β-Enals
Lewis acid B(C6F5)3 catalyzed the Diels–Alder reactions of multisubstituted open-chain dienes and α,β-enals to afford the desired products with high exo-selectivities are reported. The substituent effect of the dienes and dienophiles on the product’s stereoselectivity was thoroughly investigated, and it was found that most of the desired exo-Diels–Alder products could be obtained in good yields and with high exo-stereoselectivities.
期刊:
Organic Letters
2015
作者:
Teck-Peng Loh,Yun-He Xu,Fei-Fan Meng,Bing Jiang,Jia-Hui Zhou
DOI:10.1021/acs.orglett.5b02066