A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

Identification of suitable technologies for drinking water quality prediction: a comparative study of traditional, ensemble, cost-sensitive, outlier detection learning models and sampling algorithms

Plasma lipidomics in early pregnancy and risk of gestational diabetes mellitus: a prospective nested case-control study in Chinese women.

Biochar nanoparticles induced distinct biological effects on freshwater algae via oxidative stress, membrane damage, and nutrient depletion.

Di (2-ethyl-hexyl) Phthalate Disrupts Placental Growth in a Dual Blocking Mode

Quantitative fatty acid signature analysis (QFASA) in indoor dust: Implication for tracking indoor source accumulation of organic pollutant exposure

A prospective study of early-pregnancy thyroid markers, lipid species, and risk of gestational diabetes mellitus

Abstract Context While the associations between thyroid markers and gestational diabetes mellitus (GDM) have been extensively studied, the results are inconclusive and the mechanisms remain unclear. Objective We aimed to investigate the prospective associations of thyroid markers in early gestation with GDM risk, and examine the mediating effects through lipid species. Methods This study included 6068 pregnant women from the Tongji-Shuangliu Birth Cohort. Maternal serum thyroid markers (free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone, thyroid peroxidase antibody, and thyroglobulin antibody) were measured before 15 weeks. Deiodinase activity was assessed by fT3/fT4 ratio. Plasma lipidome were quantified in a subset of 883 participants. Results Mean age of the participants was 26.6 ± 3.7 years, and mean gestational age was 10.3 ± 2.0 weeks. Higher levels of fT4 were associated with a decreased risk of GDM (OR=0.73 comparing the extreme quartiles; 95% CI 0.54, 0.98, Ptrend =0.043), while higher fT3/fT4 ratio was associated with an increased risk of GDM (OR=1.43 comparing the extreme quartiles; 95% CI 1.06, 1.93, Ptrend =0.010) after adjusting for potential confounders. Multiple linear regression suggested that fT3/fT4 ratio was positively associated with alkylphosphatidylcholine 36:1, phosphatidylethanolamine plasmalogen 38:6, diacylglyceride 18:0/18:1, sphingomyelin 34:1, and phosphatidylcholine 40:7 (false discovery rate adjusted P

Cellular Response of Freshwater Algae to Halloysite Nanotubes: Alteration of Oxidative Stress and Membrane Function

Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation

Circulating fatty acids and risk of gestational diabetes mellitus: prospective analyses in China

Objective We aimed to examine prospective associations between circulating fatty acids in early pregnancy and incident gestational diabetes mellitus (GDM) among Chinese pregnant women. Methods Analyses were based on two prospective nested case-control studies conducted in western China (336 GDM cases and 672 matched controls) and central China (305 cases and 305 matched controls). Fasting plasma fatty acids in early pregnancy (gestational age at enrollment: 10.4 weeks [standard deviation, 2.0]) and 13.2 weeks [1.0], respectively) were determined by gas chromatography-mass spectrometry, and GDM was diagnosed based on the International Association of Diabetes in Pregnancy Study Groups criteria during 24-28 weeks of gestation. Multiple metabolic biomarkers (HOMA-IR [homeostatic model assessment for insulin resistance], HbA1c, c-peptide, high-sensitivity C-reactive protein, adiponectin, leptin, and blood lipids) were additionally measured among 672 non-GDM controls at enrollment. Results Higher levels of saturated fatty acids (SFAs) 14:0 (pooled odds ratio, 1.41 for each 1-standard deviation increase; 95% confidence interval, 1.25, 1.59) and 16:0 (1.19; 1.05, 1.35) were associated with higher odds of GDM. Higher levels of n-6 polyunsaturated fatty acid (PUFA) 18:2n-6 was strongly associated with lower odds of GDM (0.69; 0.60, 0.80). In non-GDM pregnant women, higher SFAs 14:0 and 16:0 but lower n-6 PUFA 18:2n-6 were generally correlated with unfavorable metabolic profiles. Conclusions We documented adverse associations of 14:0 and 16:0 but a protective association of 18:2n-6 with GDM among Chinese pregnant women. Our findings highlight the distinct roles of specific fatty acids in the onset of GDM.

Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)

Postnatal exposure to DINP was associated with greater alterations of lipidomic markers for hepatic steatosis than DEHP in postweaning mice

Gut Microbial Metabolite p-Cresol Alters Biotransformation of Bisphenol A: Enzyme Competition or Gene Induction?

The effect of maturity and tissue on the ability of mid infrared spectroscopy to predict the geographical origin of banana ( Musa Cavendish )

Lipidomic biomarkers: Potential mediators of associations between urinary bisphenol A exposure and colorectal cancer

Association between pyrethroid exposure and cardiovascular disease: A national population-based cross-sectional study in the US

Novel Synthetic Antioxidants in House Dust from Multiple Locations in the Asia-Pacific Region and the United States

Rice ACID PHOSPHATASE 1 regulates Pi stress adaptation by maintaining intracellular Pi homeostasis

Photodegradation of 1,3,5-Tris-(2,3-dibromopropyl)-1,3,5-triazine-2,4,6-trione and decabromodiphenyl ethane flame retardants: Kinetics, Main products, and environmental implications

Exposure to bisphenol analogues interrupts growth, proliferation, and fatty acid compositions of protozoa Tetrahymena thermophila

Rapid measurement of microplastic contamination in chicken meat by mid infrared spectroscopy and chemometrics: A feasibility study

Nutritional and Environmental Contaminant Exposure: A Tale of Two Co-Existing Factors for Disease Risks

Lipidomic Changes in Banana (Musa cavendish) during Ripening and Comparison of Extraction by Folch and Bligh–Dyer Methods

Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut

Measuring thiamine status in dried blood spots

Association of circulating saturated fatty acids with the risk of pregnancy-induced hypertension: a nested case–control study

Comparative analysis of surface water quality prediction performance and identification of key water parameters using different machine learning models based on big data

Changes to breast milk fatty acid composition during storage, handling and processing: A systematic review

DEHP and DINP Induce Tissue- and Gender-Specific Disturbances in Fatty Acid and Lipidomic Profiles in Neonatal Mice: A Comparative Study

Robust measurement of vitamin A status in plasma and blood dried on paper

Measurement of Fructose, Glucose, Maltose and Sucrose in Barley Malt Using Attenuated Total Reflectance Mid-infrared Spectroscopy