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许改霞
深圳 | 深圳大学生物医学工程学院 | 教授
  Email   xugaixia@szu.edu.cn  Phone   13510221696
论文

A biocompatible photosensitizer with a high intersystem crossing efficiency for precise two-photon photodynamic therapy

A biocompatible organic room-temperature phosphorescence photosensitizer that can be excited using two-photon near-infrared light is developed for photodynamic therapy to achieve improved oxygen species generation and tissue penetration.

期刊: Materials Horizons  2022
作者: Chengbin Yang,Runfeng Chen,Ye Tao,Gaixia Xu,Ken-Tye Yong,Biqin Dong,Mingze Ma,Wing-Cheung Law,Guimiao Lin,Zulu Hu,Lele Tang,Yuanyuan Shen,Yihang Jiang,Zhourui Xu
DOI:10.1039/d1mh01869h

BIX-01294 enhances the effect of chemotherapy on colorectal cancer by inhibiting the expression of stemness genes

期刊: Biochemical and Biophysical Research Communications  2022
作者: Xiaomei Wang,Xingsheng Shu,Gaixia Xu,Shenglan Nie,Shuling Xu,Cai Zhou,Yu Han,Zhongke Hua,Hua Yang,Yihang Jiang,Shikang Liu
DOI:10.1016/j.bbrc.2021.12.089

A mitochondrion-targeting two-photon photosensitizer with aggregation-induced emission characteristics for hypoxia-tolerant photodynamic therapy

期刊: Chemical Engineering Journal  2022
作者: Ben Zhong Tang,Gaixia Xu,Dong Wang,Ken-Tye Yong,Wing-Cheung Law,Chengbin Yang,Jianyu Zhang,Zhengzheng Li,Miaozhuang Fan,Shuo Tang,Zhijun Zhang,Zhourui Xu,Wei Zhu,Yihang Jiang
DOI:10.1016/j.cej.2022.137604

A biocompatible ratiometric fluorescent nanoprobe for intracellular hydrogen sulfide accurate detection based on rare earth nanoparticle

期刊: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy  2022
作者: Gaixia Xu,Biqin Dong,Ken-Tye Yong,Ming Ying,Xiaomei Wang,Zhourui Xu,Cong Zhao,Miaozhuang Fan,Yihang Jiang,Peng Zhai,Gang Feng,Zhengzheng Li
DOI:10.1016/j.saa.2022.121532

Self-powered triboelectric nanogenerator driven nanowires electrode array system for the urine sterilization

期刊: Nano Energy  2022
作者: Chengbin Yang,Gaixia Xu,Jia Liu,Xiang Li,Zulu Hu,Weinan Zhang,Haoqiang Huang,Xinmeng Zhang
DOI:10.1016/j.nanoen.2022.107111

Deep-Brain Three-Photon Imaging Enabled by Aggregation-Induced Emission Luminogens with Near-Infrared-III Excitation

期刊: ACS Nano  2022
作者: Gaixia Xu,Dong Wang,Ke Wang,Xiaolin Chen,Wanjian Zhang,Chengbin Yang,Wing-Cheung Law,Yihang Jiang,Jiangao Li,Xiangquan Deng,Zhijun Zhang,Zhourui Xu
DOI:10.1021/acsnano.2c01349

Synthetic Conjugated Oligoelectrolytes Are Effective siRNA Transfection Carriers: Relevance to Pancreatic Cancer Gene Therapy

期刊: Biomacromolecules  2022
作者: Guillermo C. Bazan,Ken-Tye Yong,Gaixia Xu,Haoming Lin,Zhourui Xu,Guang Yang,Cheng Zhou,Nishtha Manish Singh,Haoqiang Huang,Chengbin Yang
DOI:10.1021/acs.biomac.1c01498

Fabry-Perot Interferometer Based on a Fiber-Tip Fixed-Supported Bridge for Fast Glucose Concentration Measurement

Blood glucose concentration is important for metabolic homeostasis in humans and animals. Many diabetic patients need to detect blood glucose daily which burdens community hospitals and family healthcare. Optical fiber sensors are widely used in biomedical detection because of their compact structure, fast response, high sensitivity, low cost, and ease of operation. In this work, we constructed a Fabry-Perot (FP) cavity biosensor for the fast detection of glucose concentration in serum. The femtosecond laser micromachining was applied to fabricate the FP cavity by printing the fiber-tip fixed-supported bridge at the end face of the optical fiber. An additional hemisphere was printed at the center of the outer surface of the bridge to avoid multi-beam interference. The results demonstrated that the proposed biosensor had high refractive index (RI) detection sensitivity, roughly 1039 nm/RIU at a wavelength of 1590 nm, and the detection sensitivity for glucose was around 0.185 nm/ (mg/mL) at a wavelength of 1590 nm. Due to its high sensitivity, compact structure, and fast response, the FP cavity biosensor has great potential to be applied in family healthcare for glucose concentration detection of diabetic patients.

期刊: Biosensors  2022
作者: Gaixia Xu,Changrui Liao,Yiping Wang,Biqin Dong,Xiaomei Wang,Chengbin Yang,Zhourui Xu,Ribao Chen,Yihang Jiang,Cong Zhao,Mengqiang Zou,Shuo Tang
DOI:10.3390/bios12060391

CuS@BSA-NB2 Nanoparticles for HER2-Targeted Photothermal Therapy

Breast cancer is characterized by the uncontrolled proliferation of breast epithelial cells under the action of a variety of carcinogens. Although HER2-inhibitors were currently applied for HER2-positive breast cancer patients, they didn’t work for patients with resistance to HER2-targeted anti-cancer drugs. In this work, we prepared novel CuS@BSA-NB2 nanoparticles (NPs) for breast cancer photothermal therapy (PTT). The NPs had good biocompatibility due to the Bovine Serum Albumin (BSA) encapsulating and excellent targeting to HER2 because of nanobody 2 (NB2). Under 808 nm laser irradiation, CuS@BSA-NB2 NPs had high photothermal conversion efficiency and photothermal stability. Meanwhile, we constructed a stable cell line of MDA-MB-231/HER2 with a high expression of HER2 protein. Immunofluorescence and ICP-MS assays showed that CuS@BSA-NB2 NPs can be specifically enriched and be ingested in MDA-MB-231/HER2 cells. Furthermore, CuS@BSA-NB2 NPs had shown a more significant photothermal treatment effect than CuS@BSA under certain treatment conditions for MDA-MB-231/HER2. In addition, the cytotoxicity assay demonstrated that CuS@BSA-NB2 NPs had a low toxicity for MDA-MB-231/HER2 cells. The above results suggested that CuS@BSA-NB2 NPs were great photothermal therapeutic agents to reduce the malignant proliferation of breast epithelial cells and have potential for breast cancer therapy.

期刊: Frontiers in Pharmacology  2022
作者: Gaixia Xu,Mingze Ma,Zhourui Xu,Yihang Jiang,Jingbo Wu,Qin Li,Ming Ying
DOI:10.3389/fphar.2021.779591

NIR-II-activated biocompatible hollow nanocarbons for cancer photothermal therapy

AbstractPhotothermal therapy has attracted extensive attentions in cancer treatment due to its precise spatial-temporal controllability, minimal invasiveness, and negligible side effects. However, two major deficiencies, unsatisfactory heat conversion efficiency and limited tissue penetration depth, hugely impeded its clinical application. In this work, hollow carbon nanosphere modified with polyethylene glycol-graft-polyethylenimine (HPP) was elaborately synthesized. The synthesized HPP owns outstanding physical properties as a photothermal agent, such as uniform core-shell structure, good biocompatibility and excellent heat conversion efficiency. Upon NIR-II laser irradiation, the intracellular HPP shows excellent photothermal activity towards cancer cell killing. In addition, depending on the large internal cavity of HPP, the extended biomedical application as drug carrier was also demonstrated. In general, the synthesized HPP holds a great potential in NIR-II laser-activated cancer photothermal therapy.

期刊: Journal of Nanobiotechnology  2021
作者: Chengbin Yang,Weiping Wu,Binyuan Zhao,Tiantian Kong,Yucheng Wang,Zan Wang,Fenghua Liu.,Mingze Ma,Gaixia Xu,Lijian Wang,Weixiao Zhou,Yinling Zhang,Zhourui Xu
DOI:10.1186/s12951-021-00884-7

Recent advances of luminogens with aggregation-induced emission in multi-photon theranostics

期刊: Applied Physics Reviews  2021
作者: Ben Zhong Tang,Ken-Tye Yong,Gaixia Xu,Mark T. Swihart,Yonghong Shao,Xiaomei Wang,Ming Ying,Wing-Cheung Law,Chengbin Yang,Xiaomin Zheng,Yihang Jiang,Maixian Liu,Zhourui Xu,Miaozhuang Fan
DOI:10.1063/5.0071142

Bioengineering applications of black phosphorus and their toxicity assessment

An overall structure of this review.

期刊: Environmental Science: Nano  2021
作者: Ken-Tye Yong,Gaixia Xu,Han Zhang,Taojian Fan,Nan Qiao,Mingze Ma,Chandreyee Manas Das,Xiaomei Wang,Na Wu
DOI:10.1039/d1en00273b

Carbon Dioxide-Derived Biodegradable and Cationic Polycarbonates as a New siRNA Carrier for Gene Therapy in Pancreatic Cancer

Pancreatic cancer is an aggressive malignancy associated with poor prognosis and a high tendency in developing infiltration and metastasis. K-ras mutation is a major genetic disorder in pancreatic cancer patient. RNAi-based therapies can be employed for combating pancreatic cancer by silencing K-ras gene expression. However, the clinical application of RNAi technology is appreciably limited by the lack of a proper siRNA delivery system. To tackle this hurdle, cationic poly (cyclohexene carbonate) s (CPCHCs) using widely sourced CO2 as the monomer are subtly synthesized via ring-opening copolymerization (ROCOP) and thiol-ene functionalization. The developed CPCHCs could effectively encapsulate therapeutic siRNA to form CPCHC/siRNA nanoplexes (NPs). Serving as a siRNA carrier, CPCHC possesses biodegradability, negligible cytotoxicity, and high transfection efficiency. In vitro study shows that CPCHCs are capable of effectively protecting siRNA from being degraded by RNase and promoting a sustained endosomal escape of siRNA. After treatment with CPCHC/siRNA NPs, the K-ras gene expression in both pancreatic cancer cell line (PANC-1 and MiaPaCa-2) are significantly down-regulated. Subsequently, the cell growth and migration are considerably inhibited, and the treated cells are induced into cell apoptotic program. These results demonstrate the promising potential of CPCHC-mediated siRNA therapies in pancreatic cancer treatment.

期刊: Nanomaterials  2021
作者: Chengbin Yang,Chih-Kuang Chen,Bao-Tsan Ko,Tzu-Hsien Tsai,Wei-Chung Tsai,Ken-Tye Yong,Gaixia Xu,Zhourui Xu,Mingze Ma,Qiqi Liu,Xiang Li,Haoqiang Huang,Zulu Hu,Guan-Lin Liu,Jingyu Yang,Zheng-Ian Lin,Xinmeng Zhang
DOI:10.3390/nano11092312

High-Spatial-Resolution High-Temperature Sensor Based on Ultra-Short Fiber Bragg Gratings with Dual-Wavelength Differential Detection

期刊: Journal of Lightwave Technology  2021
作者: Yiping Wang,Gaixia Xu,Xizhen Xu,Shen Liu,Shengzhen Lu,Baijie Xu,He Li,Jun He,Kuikui Guo
DOI:10.1109/jlt.2021.3131499

Dual-Polarization Distributed Feedback Fiber Laser Sensor Based on Femtosecond Laser-Inscribed In-Fiber Stressors for Simultaneous Strain and Temperature Measurements

期刊: IEEE Access  2020
作者: Yiping Wang,Gaixia Xu,Jun He,Kuikui Guo
DOI:10.1109/access.2020.2997918

Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID‐19 SARS‐CoV‐2 Spike Protein

期刊: Advanced Theory and Simulations  2020
作者: Ken-Tye Yong,Ho‐Pui Ho,Gaixia Xu,Lixing Kang,Guang Yang,Yan Guo,Chandreyee Manas Das
DOI:10.1002/adts.202000185

Binary Organic Nanoparticles with Bright Aggregation-Induced Emission for Three-Photon Brain Vascular Imaging

期刊: Chemistry of Materials  2020
作者: Bin Liu,Gaixia Xu,Ke Wang,Ken-Tye Yong,Xunbin Wei,Xiaomei Wang,Miaozhuang Fan,Xiangquan Deng,Hongji Liu,Yukun Duan,Wenbo Wu,Bobo Gu,Maixian Liu
DOI:10.1021/acs.chemmater.0c01577

Recent advances in solar-driven evaporation systems

Solar-driven evaporation as a promising and sustainable approach to convert solar energy into freshwater resource is attracting huge interest in the research community. This review aims to summarize the recent advances in system designs of solar-driven evaporation devices.

期刊: Journal of Materials Chemistry A  2020
作者: Feng Xing,Biqin Dong,Chengbin Yang,Yanshuai Wang,Ken-Tye Yong,Wing-Cheung Law,Mingwei Zhu,Gaixia Xu,Yihang Jiang,Zida Li,Zhourui Xu
DOI:10.1039/d0ta08869b

<p>In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quantum Dots with Different Surface Modifications</p>

期刊: International Journal of Nanomedicine  2020
作者: Guimiao Lin,Dahui Xue,Wenxiao Jiang,Xiaomei Wang,Tingting Chen,Zhiwen Yang,Dongmeng Liu,Gaixia Xu,Yajing Chen,Li Li
DOI:10.2147/ijn.s241332

Systematic evaluation of CdSe/ZnS Quantum Dots toxicity on the reproduction and offspring health in male BALB/c mice

Abstract Background: Increased applications of quantum dots (QDs) in biomedical field have aroused attention for their potential toxicological effects. Although many studies have been carried out on the toxicity of QDs, their effects on reproductive and development are still unclear. In this study, we systematically evaluated the male reproductive toxicity and developmental toxicity of CdSe/ZnS QDs in BALB/c mice.Results: The male mice were injected intravenously with CdSe/ZnS QDs at the dosage of 2.5 mg/kg BW or 25 mg/kg BW, respectively, and the survival status, biodistribution of QDs in testes, serum sex hormone levels, histopathology, sperm motility and acrosome integrity was measured on Day 1, 7, 14, 28 and 42 after injection. On Day 35 after treatment, male mice were housed with non-exposed female mice, and then offspring number, body weight, organ index and histopathology of major organs, blood routine and biochemical tests of offspring were measured to evaluate the fertility and offspring health. The results showed that CdSe/ZnS QDs could rapidly distribute in the testis, and the fluorescence of QDs could still be detected on Day 42 post-injection. QDs had no adverse effect on the structure of testis and epididymis, but high-dose QDs could induce apoptosis of Leydig cells in testis at an early stage. No significant differences in survival of state, body weight organ index of testis and epididymis, sex hormones levels, sperm quality, sperm acrosome integrity and fertility of male mice were observed in QDs exposed groups. However, the development of offspring was obviously influenced, which was mainly manifested in the slow growth of offspring, changes of organ index of main organs, and the abnormality of liver and kidney function parameters.Conclusion: Our findings revealed that CdSe/ZnS QDs were able to cross the blood-testis barrier (BTB), produce no discernible toxic effects on the male reproductive system, but could affect the healthy growth of future generations to some extent. In view of the broad application prospect of QDs in biomedical fields, our findings might provide insight into the biological safety evaluation of the reproductive health of QDs.

作者: Guimiao Lin,Xiaomei Wang,Gaixia Xu,Dongmeng Liu,Yajing Chen,Zhiwen Yang,Kan Liu,Tingting Chen,Xiaotan Lin,Li Li
DOI:10.21203/rs.3.rs-35995/v1

Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation

期刊: Nanotheranostics  2020
作者: Gaixia Xu,Jiajie Kuang,Xiaorui Huang,Shuting Weng,Wenxiao Jiang,Yajing Chen,Jie Wang,Xiaomei Wang,Ken-Tye Yong,Li Li,Zhiwen Yang,Yongning Pan,Ting Chen,Guimiao Lin
DOI:10.7150/ntno.42786

Nephrotoxicity Evaluation of Indium Phosphide Quantum Dots with Different Surface Modifications in BALB/c Mice

InP QDs have shown a great potential as cadmium-free QDs alternatives in biomedical applications. It is essential to understand the biological fate and toxicity of InP QDs. In this study, we investigated the in vivo renal toxicity of InP/ZnS QDs terminated with different functional groups—hydroxyl (hQDs), amino (aQDs) and carboxyl (cQDs). After a single intravenous injection into BALB/c mice, blood biochemistry, QDs distribution, histopathology, inflammatory response, oxidative stress and apoptosis genes were evaluated at different predetermined times. The results showed fluorescent signals from QDs could be detected in kidneys during the observation period. No obvious changes were observed in histopathological detection or biochemistry parameters. Inflammatory response and oxidative stress were found in the renal tissues of mice exposed to the three kinds of QDs. A significant increase of KIM-1 expression was observed in hQDs and aQDs groups, suggesting hQDs and aQDs could cause renal involvement. Apoptosis-related genes (Bax, Caspase 3, 7 and 9) were up-regulated in hQDs and aQDs groups. The above results suggested InP/ZnS QDs with different surface chemical properties would cause different biological behaviors and molecular actions in vivo. The surface chemical properties of QDs should be fully considered in the design of InP/ZnS QDs for biomedical applications.

期刊: International Journal of Molecular Sciences  2020
作者: Gaixia Xu,Guimiao Lin,Xiaomei Wang,Shikang Liu,Jiangyao Xu,Kan Liu,Maixian Liu,Huiyu Xiao,Dongmeng Liu,Yajing Chen,Zhiwen Yang,Tingting Chen,Li Li
DOI:10.3390/ijms21197137

Simultaneous Measurement of Strain and Temperature by a Sawtooth Stressor-Assisted Highly Birefringent Fiber Bragg Grating

期刊: Journal of Lightwave Technology  2020
作者: Yiping Wang,Gaixia Xu,Laipeng Shao,Jun He,Kuikui Guo
DOI:10.1109/jlt.2019.2959671

Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans

期刊: Aging  2019
作者: Xiaomei Wang,Gaixia Xu,Yang Sun,Xiaoyun Zhang,Wen Liu,Yushu Wang,Zijun Ouyang,Tianying Zhan,Tingting Chen,Kan Liu,Jiangyao Xu
DOI:10.18632/aging.102466

Recent advances in copper sulphide-based nanoheterostructures

This tutorial summarizes and integrates recent advances in design and synthesis of copper sulfide-based nanoheterostructures and their applications in energy and healthcare.

期刊: Chemical Society Reviews  2019
作者: Ken-Tye Yong,Mark T. Swihart,Xiaomei Wang,Gaixia Xu,Xunbin Wei,Bobo Gu,Yang Liu,Maixian Liu
DOI:10.1039/c8cs00832a

The Ultrasmall Biocompatible CuS@BSA Nanoparticle and Its Photothermal Effects

期刊: Frontiers in Pharmacology  2019
作者: Gaixia Xu,Xiaomei Wang,Guimiao Lin,Zhongjun Li,Li Li,Na Wu,Danyang Chen,Mingze Ma,Maixian Liu,Xiaofang Wan
DOI:10.3389/fphar.2019.00141

Evaluation for adverse effects of InP/ZnS quantum dots on the in vitro cultured oocytes of mice

期刊: ACS Applied Bio Materials  2019
作者: Gaixia Xu,Xiaomei Wang,Guimiao Lin,Mingze Ma,Juanjie Wu,Li Li,Xianqi Ye
DOI:10.1021/acsabm.9b00484

Prognostic Significance of FOXC1 in Various Cancers: A Systematic Review and Meta-Analysis

期刊: Molecular Diagnosis & Therapy  2019
作者: Rama Jayaraj,Gaixia Xu,Xingzhi Xu,Chellan Kumarasamy,Madhav Madurantakam Royam,Shanthi Sabarimurugan,Nadana Sabapathi
DOI:10.1007/s40291-019-00416-y

Symmetric Step-Apodized Distributed Feedback Fiber Laser With Improved Efficiency

期刊: IEEE Photonics Journal  2019
作者: Yiping Wang,Gaixia Xu,Bin Du,Xizhen Xu,Zhe Zhang,Kaiming Yang,Jun He,Kuikui Guo
DOI:10.1109/jphot.2019.2921628

The Codelivery of siRNA and QDs by pH-Responsive Micelle for Hepatoma Cancer Cells

期刊: Frontiers in Pharmacology  2019
作者: Gaixia Xu,Xiaomei Wang,Ken-Tye Yong,Peng Zhai,Guimiao Lin,Maixian Liu,Li Li,Huiyu Xiao,Zhonglin Cao
DOI:10.3389/fphar.2019.01194

Nanowire-array-based gene electro-transfection system driven by human-motion operated triboelectric nanogenerator

期刊: Nano Energy  2019
作者: Zhong Lin Wang,Ken-Tye Yong,Guang Zhu,Daniel Puiu Poenar,Gaixia Xu,Peiyi Song,Shuangyang Kuang,Qingling Ouyang,Guang Yang,Chengbin Yang
DOI:10.1016/j.nanoen.2019.103901

Biomimetic Self-Renewal Polymer Brushes with Protein Resistance Inspired by Fish Skin

期刊: Langmuir  2019
作者: Chunfeng Ma,Gaixia Xu,Tiansheng Gan,Zhonglin Cao
DOI:10.1021/acs.langmuir.9b02838

In vivo comparison of the biodistribution and toxicity of InP/ZnS quantum dots with different surface functional groups

Abstract Background: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, the potential toxicity of InP QDs has not been systematically evaluated. In particular, the effects of different surface modifications on the biodistribution and toxicity of InP QDs is still unknown, which hinders their further developments. The present study aims to investigate the biodistribution and in vivo toxicity of three types of InP/ZnS QDs with different surface modifications, hQDs (QDs-OH), aQDs (QDs-NH2), and cQDs (QDs-COOH) respectively. These InP/ZnS QDs with 2.5 mg/kg BW or 25 mg/kg BW were intravenously injected into BALB/c mice. Biodistribution of three QDs was determined through cryosection fluorescence microscopy and ICP-MS analysis. The subsequent effects of InP/ZnS QDs on histopathology, hematology and blood biochemistry were evaluated at 1, 3, 7, 14 and 28 days post-injection.Results: The results showed these types of InP/ZnS QDs QDs were rapidly distributed in the major organs of mice, mainly in the liver and spleen, and lasted for 28 days. No abnormal behavior, weight change or organ index were observed during the whole observation period, except that 2 mice died on Day 1 after 25 mg/kg BW hQDs treatment. The results of H&E staining showed that no obvious histopathological abnormalities were observed in the main organs (including heart, liver, spleen, lung, kidney, and brain ) of all mice injected with different surface functionalized QDs. Low concentration exposure of three QDs hardly caused obvious toxicity, while high concentration exposure of the three QDs could cause some changes in hematological parameters or biochemical parameters related to liver function or cardiac function. More attention need to be paid on cQDs as high dose exposure of cQDs induced death, acute inflammatory reaction and slight changes in liver function in mice.Conclusions: Generally speaking, the surface modification and exposure dose can influence the biological behavior and in vivo toxicity of QDs. The surface chemistry should be fully considered in the design of InP-based QDs for their biomedical applications. Keywords: InP/ZnS quantum dots, surface chemistry, in vivo, biodistribution, nanotoxicology

作者: Guimiao Lin,Dahui Xue,Wenxiao Jiang,Xiaomei Wang,Tingting Chen,Zhiwen Yang,Dongmeng Liu,Gaixia Xu,Yajing Chen,Li Li
DOI:10.21203/rs.2.18407/v1

Black phosphorus nanosheets for rapid microRNA detection

Herein, for the first time, a sensitive sensing platform for rapid detection of microRNA was developed by employing black phosphorus nanosheets as the fluorescence quenching material.

期刊: Nanoscale  2018
作者: Gaixia Xu,Han Zhang,Liwei Cao,Xianyou Wang,Xiaomei Wang,Maixian Liu,Ming Ying,Zhongjun Li,Jie Zhou
DOI:10.1039/c7nr08900g

Beat frequency tuning in dual-polarization distributed feedback fiber laser using side polishing technique

期刊: Optics Express  2018
作者: Yiping Wang,Gaixia Xu,Zhe Zhang,Maoxiang Hou,Shaoqing Cao,Jun He,Kuikui Guo
DOI:10.1364/oe.26.034699

Cytotoxicity of InP/ZnS Quantum Dots With Different Surface Functional Groups Toward Two Lung-Derived Cell Lines

期刊: Frontiers in Pharmacology  2018
作者: Guimiao Lin,Zhiwen Yang,Wenxiao Jiang,Yajing Chen,Jie Wang,Xiaomei Wang,Gaixia Xu,Li Li,Ting Chen
DOI:10.3389/fphar.2018.00763

Biodegradable nanoparticles as siRNA carriers for in vivo gene silencing and pancreatic cancer therapy

Biodegradable charged polyester-based vectors (BCPVs) were utilized for efficiently delivering mutatedK-Ras-targeting siRNA and successfully inhibiting tumor growth in a pancreatic xenograft modelin vivo.

期刊: Journal of Materials Chemistry B  2017
作者: Ken-Tye Yong,Xiaomei Wang,Fei Lu,Jie Wang,Marie Chia-Mi Lin,Chunxiao He,Gaixia Xu,Ting Chen,Jinglin Tian,Chengbin Yang,Feng Yin,Chih-Kuang Chen,Guimiao Lin
DOI:10.1039/c6tb03116a

Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells

期刊: Frontiers in Pharmacology  2017
作者: Ken-Tye Yong,Gaixia Xu,Marie Chia-Mi Lin,Yingying Zhao,Zicai Fu,Qijun Huang,Jiefeng Li,Xiaomei Wang,Yucheng Wang,Jinyun Zou,Ting Chen,Guimiao Lin
DOI:10.3389/fphar.2017.00182

The biocompatibility studies of polymer dots on pregnant mice and fetuses

期刊: Nanotheranostics  2017
作者: Gaixia Xu,Changfeng Wu,Ken-Tye Yong,Xiaomei Wang,Ming Ying,Guimiao Lin,Yueyue Deng,Zezhou Sun,Jie Zhou,Zheng Zhang,Na Wu
DOI:10.7150/ntno.18964

Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics

期刊: advanced materials  2017
作者: Bin Liu,Ken-Tye Yong,Junle Qu,Peter Han Joo Chong,Feng Yin,Guangxue Feng,Gaixia Xu,Wenbo Wu,Bobo Gu

Sensitivity Enhancement of Transition Metal Dichalcogenides/Silicon Nanostructure-based Surface Plasmon Resonance Biosensor

期刊: Scientific Reports  2016
作者: Ken-Tye Yong,Philippe Coquet,Junle Qu,Sailing He,Jun Qian,Xuan-Quyen Dinh,Gaixia Xu,Liying Hong,Li Jiang,Shuwen Zeng,Qingling Ouyang
DOI:10.1038/srep28190

Small Photoblinking Semiconductor Polymer Dots for Fluorescence Nanoscopy

期刊: Advanced Materials  2016
作者: Yujie Sun,Changfeng Wu,Peng Xi,Gaixia Xu,Danni Chen,Zezhou Sun,Kai Sun,Zhihe Liu,Rongqin Li,Xuanze Chen
DOI:10.1002/adma.201604850

Disposable poly (o-aminophenol)-carbon nanotubes modified screen print electrode-based enzyme sensor for electrochemical detection of marine toxin okadaic acid

期刊: Sensors and Actuators B: Chemical  2016
作者: Ping Wang,Gaixia Xu,Kaiqi Su,Xianxin Qiu,Jie Zhou
DOI:10.1016/j.snb.2016.05.067

The Reproductive Toxicity of CdSe/ZnS Quantum Dots on the in vivo Ovarian Function and in vitro Fertilization

期刊: Scientific Reports  2016
作者: Xiaomei Wang,Ken-Tye Yong,Shujiang Mei,Hanben Niu,Siping Chen,Danni Chen,Junle Qu,Qiang Chen,Gang Feng,Yueyue Deng,Na Wu,Suxia Lin,Guimiao Lin,Gaixia Xu
DOI:10.1038/srep37677

New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine

期刊: Chemical Reviews  2016
作者: Paras N. Prasad,Ken-Tye Yong,Mark T. Swihart,Butian Zhang,Shuwen Zeng,Gaixia Xu
DOI:10.1021/acs.chemrev.6b00290

A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma

期刊: Journal of Translational Medicine  2015
作者: Guangyi Jin,Marie Chia-Mi Lin,Yuwen Diao,Yu Liu,Zhiming Cai,Xiaomei Zhu,Gaixia Xu,Chuanxia Zhang,Wanxian Yi,Xiaomei Wang,Guimiao Lin
DOI:10.1186/s12967-015-0524-y

In vivo toxicity assessment of non-cadmium quantum dots in BALB/c mice

期刊: Nanomedicine: Nanotechnology, Biology and Medicine  2015
作者: Ken-Tye Yong,Xiaomei Wang,Qiang Chen,Gaixia Xu,Feng Yin,Jinglin Tian,Zhangchi Ding,Rui Hu,Qingling Ouyang,Guimiao Lin
DOI:10.1016/j.nano.2014.10.002

Three dimensional multi-molecule tracking in thick samples with extended depth-of-field

期刊: Optics Express  2015
作者: Hanben Niu,Bin Yu,Gaixia Xu,Danni Chen,Heng Li
DOI:10.1364/oe.23.000787

Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo

Folic acid-conjugated fluorescent silica nanoparticles with biocompatibility and high-selectivity show great potential forin vivotumor imaging.

期刊: Journal of Materials Chemistry B  2015
作者: Ken-Tye Yong,Gaixia Xu,Kuan Wang,Chengbin Yang,Jinglin Tian,Guimiao Lin,Shuwen Zeng,Butian Zhang,Feng Yin
DOI:10.1039/c5tb00587f

Analysis of Pirlimycin Residues in Beef Muscle, Milk, and Honey by a Biotin–Streptavidin-Amplified Enzyme-Linked Immunosorbent Assay

期刊: Journal of Agricultural and Food Chemistry  2015
作者: Gaixia Xu,Xiaomei Wang,Guimiao Lin,Nan Wu,Peng Zhai,Pengjie Luo,Ross C. Beier,Wenxiao Jiang
DOI:10.1021/acs.jafc.5b05711

The application of quantum dots for the melanoma tumor in vivo imaging

期刊: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)  2014
作者: Gaixia Xu,Qiang Chen,Guimiao Lin,Xiaomei Zhu,Jinbo Wu,Ming Ying,Xiaomei Wang,Peng Zhai,Yayi Feng
DOI:10.1117/12.2069011

The effect of polymer dots on bioactivity of mouse sperm in vitro

期刊: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)  2014
作者: Danni Chen,Gaixia Xu,Guimiao Lin,Xiaomei Wang,Peng Zhai,Qiang Chen,Gang Feng
DOI:10.1117/12.2069061

The toxicity and invasive effects of QDs on mung bean development

期刊: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)  2014
作者: Danni Chen,Gaixia Xu,Qiang Chen,Guimiao Lin,Gang Feng,Xuan Huang,Ruhua Wang,Xiaomei Wang,Peng Zhai
DOI:10.1117/12.2069000

Cytotoxicity and immune response of CdSe/ZnS Quantum dots towards a murine macrophage cell line

期刊: RSC Advances  2014
作者: Ken-Tye Yong,Gaixia Xu,Delin Lei,Fangqi Lu,Jinghua Liang,Kan Liu,Xiaomei Zhu,Qiang Chen,Xiaomei Wang,Rui Hu,Zhangchi Ding,Guimiao Lin
DOI:10.1039/c3ra45335a

Theranostic quantum dots for crossing blood–brain barrier in vitro and providing therapy of HIV-associated encephalopathy

期刊: Frontiers in Pharmacology  2013
作者: Ken-Tye Yong,Indrajit Roy,Supriya Mahajan,Gaixia Xu
DOI:10.3389/fphar.2013.00140

Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells

期刊: Small  2013
作者: Ken-Tye Yong,Chong Cheng,Ling Ye,Gaixia Xu,Xiaomei Wang,Ho Sup Yoon,Cheng Kee Lai,Quoc Toan Nguyen,Hui Li Chin,Yucheng Wang,Chih-Kuang Chen,Wing-Cheung Law,Rui Hu,Guimiao Lin
DOI:10.1002/smll.201201716

Approach to multiparticle parallel tracking in thick samples with three-dimensional nanoresolution

期刊: Optics Letters  2013
作者: Hanben Niu,Gaixia Xu,Bo Cao,Yingdong Huo,Heng Li,Bin Yu,Danni Chen
DOI:10.1364/ol.38.003712

Early Growth Response Protein-1 Promoter-Mediated Synergistic Antitumor Effect of hTERTC27 Gene Therapy and 5-Flurorouracil on Nasopharyngeal Carcinoma

期刊: Cancer Biotherapy and Radiopharmaceuticals  2012
作者: Baoxue Yang,Xiaomei Wang,Jing Yu,Siping Chen,Samuel Sai-Ming Ng,Gaixia Xu,Wanxian Yi,Shuihong Yu,Hong Yao,Suxia Lin,Marie Chia-Mi Lin,Guimiao Lin
DOI:10.1089/cbr.2011.1153

WITHDRAWN: Synthesis and Characterization of Anticancer Drug and Antibody conjugated Quantum Dots as A Novel Theranostic Probe for Pancreatic Cancer Detection and Therapy

期刊: European Journal of Pharmaceutical Sciences  2011
作者: Paras N. Prasad,Earl J. Bergey,Wing-Cheung Law,Fang Wu,Gaixia Xu,Indrajit Roy,Ken-Tye Yong,Hong Ding
DOI:10.1016/j.ejps.2011.06.016

Engineering arginine cross-linked mercaptoundecanoic acid CdSe/CdS/ZnS quantum dots for two-photon imaging of live cancer cells

期刊: Chemical Communications  2011
作者: Indrajit Roy,Gaixia Xu,Ken-Tye Yong
DOI:10.1039/c0cc05041e

FGF2-Labeled Semiconductor Nanocrystals as Luminescent Biolabels for Imaging Neuroblastoma Cells

期刊: Journal of Biomedical Nanotechnology  2010
作者: Atcha Kopwitthaya,Indrajit Roy,Ken-Tye Yong,Gaixia Xu
DOI:10.1166/jbn.2010.1164

Enhancing the Delivery of Anti Retroviral Drug “Saquinavir” Across the Blood Brain Barrier Using Nanoparticles

期刊: Current HIV Research  2010
作者: Stanley A. Schwartz,Paras N. Prasad,Elaine Y. Lin,Bindukumar B. Nair,Donald E. Sykes,Jessica L. Reynolds,Ravikumar Aalinkeel,Hong Ding,Ken-Tye Yong,Gaixia Xu,Indrajit Roy,Supriya D. Mahajan
DOI:10.2174/157016210791330356

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