Xia Lab-Radical Mass Spectrometry

2. PB-MS/MS developed by our group

32. Jing Zhao, Mengxuan Fang, Yu Xia*, “A Liquid Chromatography-Mass Spectrometry Workflow for In-Depth Quantitation of Fatty Acid Double Bond Location Isomers”J. Lipid. Res. 2021, Available online 24 August .


31. Qingyuan Hu, Yu Xia*, Xiaoxiao Ma*, “Comprehensive Structural Characterization of Lipids by Coupling Paternò–Büchi Reaction and Tandem Mass Spectrometry”, In: Hsu FF. (eds) Mass Spectrometry-Based Lipidomics. Methods in Molecular Biology, vol 2306. Humana, New York, NY.


30. Tian Xia, Ming Yuan, Yongwei Xu, Feng Zhou, Kate Yu*, and Yu Xia*, “Deep Structural Annotation of Glycerolipids by the Charge-Tagging Paterno–Büchi Reaction and Supercritical Fluid Chromatography–Ion Mobility Mass Spectrometry", Anal. Chem. 2021, 93, 23, 8345–8353


29. Hanlin Ren, Alexander Triebl, Sneha Muralidharan, Markus R. Wenk*, Yu Xia* and Federico Torta*, "Mapping the Distribution of Double Bond Location Isomers in Lipids across Mouse Tissues", Analyst, 2021,146, 3899-3907


28. X. Ma, Y. Xia, "Unsaturated Lipid Analysis via Coupling the Paternò–Büchi Reaction with ESI-MS/MS", Lipidomics. 2020: 148-174.

27. Xue Zhao, Gang Wu, Wenpeng Zhang, Mengqiu Dong, and Yu Xia*, "Resolving Modifications on Sphingoid Base and N-Acyl Chain of Sphingomyelin Lipids in Complex Lipid Extracts", Anal. Chem. 2020, 92, 21, 14775–14782


26. Jing Zhao, Xiaobo Xie, Qiaohong Lin, Xiaoxiao Ma, Pei Su, Yu Xia*, "Next-Generation Paternò–Büchi Reagents for Lipid Analysis by Mass Spectrometry", Anal. Chem. 2020, 92, 19, 13470–13477


25. Elissia T. Franklin, Yu Xia*, "Structural elucidation of triacylglycerol using online acetone Paternò–Büchi reaction coupled with reversed-phase liquid chromatography mass spectrometry" , Analyst. 2020, 145, 6532-6540.


24. Elissia Franklin, Samuel Shields, Jeffrey Manthorpe, Jeffrey C. Smith, Yu Xia, Scott A. Mcluckey*, "Coupling Headgroup and Alkene Specific Solution Modifications with Gas-Phase Ion/Ion Reactions for Sensitive Glycerophospholipid Identification and Characterization", J. Am. Soc. Mass Spectrom. 2020, 31, 4, 938–945.


23. Wenpeng Zhang*, Bing Shang, Zheng Ouyang, Yu Xia*, "Enhanced Phospholipid Isomer Analysis by Online Photochemical Derivatization and RPLC-MS", Anal. Chem. 2020, 92, 9, 6719–6726.


22. Tian Xia, Hanlin Ren, Wenpeng Zhang, Yu Xia*, "Lipidome-Wide Characterization of Phosphatidylinositols and Phosphatidylglycerols on C=C Location Level", Analytica Chimica Acta, 2020, 1128, 107-115.


21. Wenbo Cao, Simin Cheng, Jing Yang, Wenpeng Zhang, Zishuai Li, Qinhua Chen, Yu Xia, Zheng Ouyang*, Xiaoxiao Ma*, "Large-scale lipid analysis with C=C location and sn-position isomer resolving power", Nat Commun, 2020, 11, 375.


20. 马潇潇,胡清源,瑕瑜*, "Paternò-Büchi(PB)反应与串联质谱结合实现不饱和脂质精确结构解析", 分析测试学报, 2020, 39(1), 19-27.


19. Xiaobo Xie, Jing Zhao, Miao Lin, Jinlan Zhang, Yu Xia*, "Profiling of Cholesteryl Esters by Coupling Charge Tagging Paternò-Büchi Reaction and Liquid Chromatography-Mass Spectrometry", Anal. Chem. 2020, 92, 12, 8487–8496.


18. Haifang Li, Wenbo Cao, Xiaoxiao Ma, Xiaobo Xie, Yu Xia, Zheng Ouyang*, "Visible-Light-Driven [2 + 2] Photocycloadditions between Benzophenone and C=C Bonds in Unsaturated Lipids", J. Am. Chem. Soc. 2020, 142, 7, 3499–3505.


17. Wenpeng Zhang, Bing Shang, Yu Xia, "Comprehensive Characterization of Phospholipid Isomers in Human Platelets", J. Anal. Test., 2020, 4, 210–216.


16. Q. Lin, D. Zhang, Y. Xia*, "Analysis of Ether Glycerophosphocholines at the Level of C=C Locations from Human Plasma", Analyst, 2020, 145, 513-522.


15. X. Zhao, W. Zhang, D. Zhang, X. Liu, W. Cao, Q. Chen, Z. Ouyang, Y. Xia*, "A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines", Chem. Science, 2019, 10, 10740-10748.


14. Y. Su, J. Page, X. Ma, R. Shi, Y. Xia*, Zheng Ouyang*, "Mapping Lipid C=C Location Isomers in Organ Tissues by Coupling Photochemical Derivatization and Rapid Extractive Mass Spectrometry", Int. J. Mass Spectrom. 2019, 445, 116206


13. Elissia T. Franklin, Stella K. Betancourt, Caitlin E. Randolph, Scott A. McLuckey* , and Yu Xia* ,"In-depth structural characterization of phospholipids by pairing solution photochemical reaction with charge inversion ion/ion chemistry",  Anal Bioanal Chem. 2019, 411, 4739–4749.


12. R. Zou, W. Cao, L. Chong, W. Hua, H. Xu, Y. Mao, J. Page, R. Shi, Y. Xia, Tony Y. Hu, W. Zhang*, and Z. Ouyang*, "Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer", Anal. Chem. 2019, 91, 1, 1157–1163


11. X. Xie, Y. Xia*, "Analysis of Conjugated Fatty Acid Isomers by the Paternò-Büchi Reaction and Trapped Ion Mobility Mass Spectrometry", Anal. Chem. 2019, 91, 7173-7180.


10. W. Zhang, S. Chiang, Z. Li, Q. Chen, Y. Xia, Z. Ouyang*, "A Polymer Coating Transfer Enrichment for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples", Angew. Chem., Int. Ed., 2019, 58, 6064-6069.


9. W. Zhang, D. Zhang, Q. Chen, J. Wu, Z. Ouyang*, Y. Xia*, "Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers", Nat. Commun., 2019, 10, 79.


8. L. Chong, R. Tian, R. Shi, Z. Ouyang*, and Y. Xia*, "Coupling the Paternò-Büchi (PB) Reaction With Mass Spectrometry to Study Unsaturated Fatty Acids in Mouse Model of Multiple Sclerosis", Front. Chem. 2019, 7:807.


7. F. Tang*, C. Guo, X. Ma, J. Zhang, Y. Su, R. Tian, R. Shi, Y. Xia, X. Wang, Z. Ouyang*, "Rapid in situ Profiling of Lipid C=C Location Isomers in Tissue Using Ambient Mass Spectrometry with Photochemical Reactions", Anal. Chem. 2018, 90, 5612-5619


6. J. Li, S. Condello, J. T. Pepin, X. Ma, Y. Xia, T. D. Hurley, D. Matei*, and J. Cheng*, “Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells”, Cell Stem Cell, 2017, 20, 3, 301-314


5. J. Ren, E.T. Franklin, Y. Xia*, "Uncovering Structural Diversity of Unsaturated Fatty Acyls in Cholesteryl Esters via Photochemical Reaction and Tandem Mass Spectrometry", J. Am. Soc. Mass Spectrom. 2017, 28, 1432-1441


4. X. Ma, X. Zhao, J. Li, W. Zhang, J.-X. Cheng, Z. Ouyang*, Y. Xia*, "Photochemical Tagging for Quantitation of Unsaturated Fatty Acids by Mass Spectrometry", Anal. Chem. 2016, 88, 8931–8935


3. C. A. Stinson, Y. Xia*, "A Method of coupling Paternò-Büchi reaction with direct infusion ESI-MS/MS for locating C=C bond in glycerophospholipids", Analyst, 2016, 141, 3696-3704


2. X. Ma, L. Chong, R. Tian, R. Shi, T. Y. Hu, Z. Ouyang*, Y. Xia*, "Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction", Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578. Featured by C&E News and Nature Methods


1. X. Ma and Y. Xia*, "Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry", Angew. Chem., Int. Ed, 2014, 53, 2592-2596.


Created: Aug 01, 2020 | 21:38