Our research focuses on the mass spectrometry, including the instrumentation, methods development and applications. This mass spectrometric study has become the intersection of multidisciplinary researches, such as chemistry, biology medicine and material science. We are very interested in biological mass spectrometric analysis, especially the bio-omics researches by using chemical biological and bioinformatic approaches. The predominant advantages of mass spectrometry in quanlification and quantification promoted the rapid development of modern biological and life sciences. We are focusing on the unsolved difficulties behind the mass spectrometry-based proteomics, metabolomics, lipidomics and integrated bio-omics. For example, the deep analysis and exploration of the biological functions of isomeric bioactive molecules, and reveal their important roles in the diagnostics, development and therapy of critial diseases. By the development of unique mass spectrometric methods, we could uncover the mysterious molecular mechanism behind the physicological and pathological processes of living systems.