Pengda Ma's Lab

Plant secondary metabolism

硕士研究生何迪、任雅飞等发表《Phytomedicine》

论文题目:Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries

论文作者:Di He#, Yafei Ren#, Xin Hua, Jiao Zhang, Bin Zhang, Juane Dong, Thomas Efferth*, Pengda Ma(通讯作者)**

论文摘要:Background: Edible fungi resources have good application prospects in the research and development of food, medicine, and health products. Polyporus umbellatus (Pers.) Fries, as a precious edible and medicinal fungus, has long been used by Chinese medicine to treat urinary systems and related kidney diseases.

Purpose: In recent years, researchers have discovered and isolated a variety of active compounds from P. umbellatus. Modern phytochemical and pharmacological experiments showed that the crude extract of P. umbellatus had many biological functions and could be widely used in the fields of food, pharmaceutical and cosmetics. This paper summarizes the active components of P. umbellatus, through elaborating its mechanism of action, further clarify the action substances, in order to improve the utilization rate of P. umbellatus, promote the development and application of P. umbellatus in food, pharmaceutical and cosmetics industry.

Methods: In this paper, the literatures related to P. umbellatus were summarized and classified by "China National Knowledge Instructure (CNKI)", "Google Scholar" and "Web of Science". Compared with other articles, this work systematically sorted out all the active substances with clear structures in P. umbellatus. On this basis, combined with the chemical composition of P. umbellatus, its functional efficacy was expounded, and the effects of different types of active substances in P. umbellatus were further presented. 

Results: The main chemical constituents of P. umbellatus include polysaccharide and sterol, and the secondary compounds include fatty acids, phenols and other small molecules. These active substances endowed P. umbellatus anti-cancer, antibacterial, diuretic, antioxidant, enhance immune system, promote hair growth and other pharmacological activities, which has been verified many times in vivo and in vitro experiments.

Conclusion: Modern in vitro or in vivo pharmacological experiments and clinical practice for the efficacy of P. umbellatus provides a strong support, and the separation of compounds in P. umbellatus has also deepened people's understanding of this traditional Chinese medicine, greatly promoted the development and application of P. umbellatus. However, the complex active substances of poring also hinder the research of P. umbellatus to some extent, and the mechanism of action and potential synergistic or antagonistic effect of the mixture of various active ingredients have not been clearly analyzed. How to use the bioactivity-guided separation strategy to identify more bioactive components and analyze the molecular mechanism of the main active components have become the main problems of P. umbellatus research, but also provides a direction for the further study of it.

食用菌资源在食品、药品、保健品的研发中具有良好的应用前景。猪苓作为一种珍贵的食用和药用真菌,长期以来一直被中医用于治疗泌尿系统和相关的肾脏疾病。近年来,研究人员从猪苓中发现并分离出多种活性化合物。现代植物化学和药理实验表明,猪苓粗提物具有多种生物学功能,可广泛应用于食品、医药和化妆品领域。本文通过阐述猪苓的活性成分作用机理,进一步阐明其作用物质,以提高猪苓的利用率,促进猪苓在食品、医药和化妆品行业的开发和应用。

猪苓的主要化学成分包括多糖和甾醇,次生化合物包括脂肪酸、酚类等小分子物质。这些活性物质赋予了猪苓抗癌、抗菌、利尿、抗氧化、增强免疫系统、促进毛发生长等多种药理活性。现代体外或体内药理实验和临床实践为猪苓的药效提供了有力的支持,而猪苓中化合物的分离也加深了人们对这种传统中药的认识,极大地促进了猪苓的开发和应用。然而,复杂的物质也在一定程度上阻碍了对猪苓的研究,各种活性成分混合物的作用机制和潜在的协同或拮抗作用尚未得到明确分析。如何利用生物活性导向的分离策略来鉴定更多的生物活性成分,分析主要活性成分的分子机制,已成为猪苓研究的主要问题,也为其进一步研究提供了方向。

图1 猪苓的生物学功能

西北农林科技大学生命科学学院硕士生何迪和任雅菲,为本文共同第一作者。西北农林科技大学生命科学学院麻鹏达副教授和约翰内斯·古腾堡大学药物生物学系Thomas Efferth教授为论文共同通讯作者。

论文链接:https://doi.org/10.1016/j.phymed.2022.154196

Created: Jun 07, 2022 | 10:38